Zinc intake and plasma/serum zinc concentration: a systematic review and meta-analysis of randomized controlled trials

M. Warthon-Medina; C. Dullemeijer; A.L. Skinner; V.H. Moran

doi:10.1016/j.jtemb.2011.08.001

Zinc intake and plasma/serum zinc concentration: a systematic review and meta-analysis of randomized controlled trials

M. Warthon-Medina, C. Dullemeijer, A.L. Skinner, V.H. Moran

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A systematic review of randomized controlled trials (RCTs) was conducted to investigate how Zn intake influences plasma/serum Zn concentrations. We used protocols developed by EURRECA to perform a literature search for papers published up until February 2010 through MEDLINE, EMBASE, and Cochrane Library CENTRAL. We extracted data from studies that investigated apparently healthy adults and elderly, and conducted the metaanalysis using STATA (11.0). The relationship between Zn intake and plasma/serum Zn concentrations following intervention was expressed as a regression coefficient (beta), i.e., the gradient of the response curve expressed on a natural log scale. The final metaanalysis included 31 data sets from 15 RCTs. Pooled data revealed a significant relationship between Zn intake and plasma/serum Zn concentrations with an overall beta value of 0.14 (95% CI 0.11-0.18, P

Original language	English
Pages (from-to)	36
Journal	Journal of Trace Elements in Medicine and Biology
Volume	26
Issue number	S1
DOIs	https://doi.org/10.1016/j.jtemb.2011.08.001
Publication status	Published - 2011

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abstract = "A systematic review of randomized controlled trials (RCTs) was conducted to investigate how Zn intake influences plasma/serum Zn concentrations. We used protocols developed by EURRECA to perform a literature search for papers published up until February 2010 through MEDLINE, EMBASE, and Cochrane Library CENTRAL. We extracted data from studies that investigated apparently healthy adults and elderly, and conducted the metaanalysis using STATA (11.0). The relationship between Zn intake and plasma/serum Zn concentrations following intervention was expressed as a regression coefficient (beta), i.e., the gradient of the response curve expressed on a natural log scale. The final metaanalysis included 31 data sets from 15 RCTs. Pooled data revealed a significant relationship between Zn intake and plasma/serum Zn concentrations with an overall beta value of 0.14 (95\% CI 0.11-0.18, P",

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AU - Moran, V.H.

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Zinc intake and plasma/serum zinc concentration: a systematic review and meta-analysis of randomized controlled trials

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