Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging

K.M. Spoorendonk, C.L. Hammond, L.F.A. Huitema, J. Vanoevelen, S. Schulte-Merker

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Abstract

For many years bone research has been mainly performed in mice, chicken, cell culture systems or human material from the clinic. In this review, we describe the features of zebrafish (Danio rerio), a relatively new model system in this field. This small teleost offers possibilities which make it a great complement to the mouse: forward genetic screens are possible in fish due to extrauterine development and large brood size, and the recent generation of osteoblast-specific reporter lines allows visualization of osteoblasts in vivo. As key regulators of bone formation are highly conserved between mammals and teleosts, findings in fish likely apply to mammalian osteogenesis and tissue mineralization
Original languageEnglish
Pages (from-to)219-224
JournalJournal of Applied Ichthyology
Volume26
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

osteoblasts
bone formation
teleost
Danio rerio
bone
bones
image analysis
brood size
mice
fish
visualization
mineralization
complement
cell culture
mammal
mammals
chickens
tissues
tissue
material

Keywords

  • danio-rerio ostariophysi
  • osteoblast differentiation
  • skeletal elements
  • axial skeleton
  • retinoic acid
  • chondrocytes
  • expression
  • mutations
  • osteogenesis
  • cyprinidae

Cite this

Spoorendonk, K. M., Hammond, C. L., Huitema, L. F. A., Vanoevelen, J., & Schulte-Merker, S. (2010). Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Journal of Applied Ichthyology, 26(2), 219-224. https://doi.org/10.1111/j.1439-0426.2010.01409.x
Spoorendonk, K.M. ; Hammond, C.L. ; Huitema, L.F.A. ; Vanoevelen, J. ; Schulte-Merker, S. / Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. In: Journal of Applied Ichthyology. 2010 ; Vol. 26, No. 2. pp. 219-224.
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Spoorendonk, KM, Hammond, CL, Huitema, LFA, Vanoevelen, J & Schulte-Merker, S 2010, 'Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging', Journal of Applied Ichthyology, vol. 26, no. 2, pp. 219-224. https://doi.org/10.1111/j.1439-0426.2010.01409.x

Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. / Spoorendonk, K.M.; Hammond, C.L.; Huitema, L.F.A.; Vanoevelen, J.; Schulte-Merker, S.

In: Journal of Applied Ichthyology, Vol. 26, No. 2, 2010, p. 219-224.

Research output: Contribution to journalArticleAcademicpeer-review

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