WormQTL—public archive and analysis web portal for natural variation data in Caenorhabditis spp

L.B. Snoek, K.J. van der Velde, D. Arends, Y. Li, A. Beyer, M. Elvin, J. Fisher, A. Hajnal, M. Hengartner, G. Poulin, M. Rodriguez Sanchez, T. Schmid, S. Schrimpf, F. Xue, R.C. Jansen, J.E. Kammenga, M.A. Swertz

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Abstract

Here, we present WormQTL (http://www.wormqtl.org), an easily accessible database enabling search, comparative analysis and meta-analysis of all data on variation in Caenorhabditis spp. Over the past decade, Caenorhabditis elegans has become instrumental for molecular quantitative genetics and the systems biology of natural variation. These efforts have resulted in a valuable amount of phenotypic, high-throughput molecular and genotypic data across different developmental worm stages and environments in hundreds of C. elegans strains. WormQTL provides a workbench of analysis tools for genotype–phenotype linkage and association mapping based on but not limited to R/qtl (http://www.rqtl.org). All data can be uploaded and downloaded using simple delimited text or Excel formats and are accessible via a public web user interface for biologists and R statistic and web service interfaces for bioinformaticians, based on open source MOLGENIS and xQTL workbench software. WormQTL welcomes data submissions from other worm researchers.
Original languageEnglish
Pages (from-to)D738-D743
JournalNucleic acids research
Volume41
Issue numberD1
DOIs
Publication statusPublished - 2013

    Fingerprint

Keywords

  • life-history traits
  • c. elegans
  • systems biology
  • qtl
  • polymorphism
  • genotype
  • environment
  • plasticity
  • platform
  • genome

Cite this

Snoek, L. B., van der Velde, K. J., Arends, D., Li, Y., Beyer, A., Elvin, M., ... Swertz, M. A. (2013). WormQTL—public archive and analysis web portal for natural variation data in Caenorhabditis spp. Nucleic acids research, 41(D1), D738-D743. https://doi.org/10.1093/nar/gks1124