Whole-genome resequencing of 445 Lactuca accessions reveals the domestication history of cultivated lettuce

Tong Wei, Rob Van Treuren*, Xinjiang Liu, Zhaowu Zhang, Jiongjiong Chen, Yang Liu, Shanshan Dong, Peinan Sun, Ting Yang, Tianming Lan, Xiaogang Wang, Zhouquan Xiong, Yaqiong Liu, Jinpu Wei, Haorong Lu, Shengping Han, Jason C. Chen, Xuemei Ni, Jian Wang, Huanming YangXun Xu, Hanhui Kuang, Theo Van Hintum, Xin Liu*, Huan Liu*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

99 Citations (Scopus)

Abstract

Lettuce (Lactuca sativa) is an important vegetable crop worldwide. Cultivated lettuce is believed to be domesticated from L. serriola; however, its origins and domestication history remain to be elucidated. Here, we sequenced a total of 445 Lactuca accessions, including major lettuce crop types and wild relative species, and generated a comprehensive map of lettuce genome variations. In-depth analyses of population structure and demography revealed that lettuce was first domesticated near the Caucasus, which was marked by loss of seed shattering. We also identified the genetic architecture of other domestication traits and wild introgressions in major resistance clusters in the lettuce genome. This study provides valuable genomic resources for crop breeding and sheds light on the domestication history of cultivated lettuce.
Original languageEnglish
Pages (from-to)752-760
JournalNature Genetics
Volume53
Issue number5
Early online date12 Apr 2021
DOIs
Publication statusPublished - 2021

Fingerprint

Dive into the research topics of 'Whole-genome resequencing of 445 Lactuca accessions reveals the domestication history of cultivated lettuce'. Together they form a unique fingerprint.
  • Lactuca population sequencing

    Wei, T. (Creator), Van Treuren, R. (Creator), Liu, X. (Creator), Zhang, Z. (Creator), Chen, J. (Creator), Liu, Y. (Creator), Dong, S. (Creator), Sun, P. (Creator), Yang, T. (Creator), Lan, T. (Creator), Wang, X. (Creator), Xiong, Z. (Creator), Liu, Y. (Creator), Wei, J. (Creator), Lu, H. (Creator), Han, S. (Creator), Chen, J. C. (Creator), Ni, X. (Creator), Wang, J. (Creator), Yang, H. (Creator), Xu, X. (Creator), Kuang, H. (Creator), Van Hintum, T. (Creator), Liu, X. (Creator) & Liu, H. (Creator), Beijing Genome Institute (BGI), 21 Jan 2021

    Dataset

Cite this