Whole-genome association study for milk protein composition in dairy cattle

G.C.B. Schopen; M.H.P.W. Visker; P.D. Koks; E. Mullaart; J.A.M. van Arendonk; H. Bovenhuis

doi:10.3168/jds.2010-4030

Whole-genome association study for milk protein composition in dairy cattle

G.C.B. Schopen, M.H.P.W. Visker, P.D. Koks, E. Mullaart, J.A.M. van Arendonk, H. Bovenhuis

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Abstract

Our objective was to perform a genome-wide association study for content in bovine milk of aS1-casein (aS1-CN), aS2-casein (aS2-CN), ß-casein (ß-CN), ¿-casein (¿-CN), a-lactalbumin (a-LA), ß-lactoglobulin (ß-LG), casein index, protein percentage, and protein yield using a 50K single nucleotide polymorphism (SNP) chip. In total, 1,713 Dutch Holstein-Friesian cows were genotyped for 50,228 SNP and a 2-step association study was performed. The first step involved a general linear model and the second step used a mixed model accounting for all family relationships. Associations with milk protein content and composition were detected on 20 bovine autosomes. The main genomic regions associated with milk protein composition or protein percentage were found on chromosomes 5, 6, 11, and 14. The number of chromosomal regions showing significant (false discovery rate

Original language	English
Pages (from-to)	3148-3158
Journal	Journal of Dairy Science
Volume	94
Issue number	6
DOIs	https://doi.org/10.3168/jds.2010-4030
Publication status	Published - 2011

Keywords

quantitative trait loci
genetic-polymorphism
beta-lactoglobulin
missense mutation
alpha-lactalbumin
multiple levels
mixed-model
bovine-milk
casein
yield

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10.3168/jds.2010-4030

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title = "Whole-genome association study for milk protein composition in dairy cattle",

abstract = "Our objective was to perform a genome-wide association study for content in bovine milk of aS1-casein (aS1-CN), aS2-casein (aS2-CN), {\ss}-casein ({\ss}-CN), ¿-casein (¿-CN), a-lactalbumin (a-LA), {\ss}-lactoglobulin ({\ss}-LG), casein index, protein percentage, and protein yield using a 50K single nucleotide polymorphism (SNP) chip. In total, 1,713 Dutch Holstein-Friesian cows were genotyped for 50,228 SNP and a 2-step association study was performed. The first step involved a general linear model and the second step used a mixed model accounting for all family relationships. Associations with milk protein content and composition were detected on 20 bovine autosomes. The main genomic regions associated with milk protein composition or protein percentage were found on chromosomes 5, 6, 11, and 14. The number of chromosomal regions showing significant (false discovery rate",

keywords = "quantitative trait loci, genetic-polymorphism, beta-lactoglobulin, missense mutation, alpha-lactalbumin, multiple levels, mixed-model, bovine-milk, casein, yield",

author = "G.C.B. Schopen and M.H.P.W. Visker and P.D. Koks and E. Mullaart and {van Arendonk}, J.A.M. and H. Bovenhuis",

year = "2011",

doi = "10.3168/jds.2010-4030",

language = "English",

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pages = "3148--3158",

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TY - JOUR

T1 - Whole-genome association study for milk protein composition in dairy cattle

AU - Schopen, G.C.B.

AU - Visker, M.H.P.W.

AU - Koks, P.D.

AU - Mullaart, E.

AU - van Arendonk, J.A.M.

AU - Bovenhuis, H.

PY - 2011

Y1 - 2011

N2 - Our objective was to perform a genome-wide association study for content in bovine milk of aS1-casein (aS1-CN), aS2-casein (aS2-CN), ß-casein (ß-CN), ¿-casein (¿-CN), a-lactalbumin (a-LA), ß-lactoglobulin (ß-LG), casein index, protein percentage, and protein yield using a 50K single nucleotide polymorphism (SNP) chip. In total, 1,713 Dutch Holstein-Friesian cows were genotyped for 50,228 SNP and a 2-step association study was performed. The first step involved a general linear model and the second step used a mixed model accounting for all family relationships. Associations with milk protein content and composition were detected on 20 bovine autosomes. The main genomic regions associated with milk protein composition or protein percentage were found on chromosomes 5, 6, 11, and 14. The number of chromosomal regions showing significant (false discovery rate

AB - Our objective was to perform a genome-wide association study for content in bovine milk of aS1-casein (aS1-CN), aS2-casein (aS2-CN), ß-casein (ß-CN), ¿-casein (¿-CN), a-lactalbumin (a-LA), ß-lactoglobulin (ß-LG), casein index, protein percentage, and protein yield using a 50K single nucleotide polymorphism (SNP) chip. In total, 1,713 Dutch Holstein-Friesian cows were genotyped for 50,228 SNP and a 2-step association study was performed. The first step involved a general linear model and the second step used a mixed model accounting for all family relationships. Associations with milk protein content and composition were detected on 20 bovine autosomes. The main genomic regions associated with milk protein composition or protein percentage were found on chromosomes 5, 6, 11, and 14. The number of chromosomal regions showing significant (false discovery rate

KW - quantitative trait loci

KW - genetic-polymorphism

KW - beta-lactoglobulin

KW - missense mutation

KW - alpha-lactalbumin

KW - multiple levels

KW - mixed-model

KW - bovine-milk

KW - casein

KW - yield

U2 - 10.3168/jds.2010-4030

DO - 10.3168/jds.2010-4030

M3 - Article

VL - 94

SP - 3148

EP - 3158

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

IS - 6

ER -

Whole-genome association study for milk protein composition in dairy cattle

Abstract

Keywords

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