Whole-genome association study for milk protein composition in dairy cattle

G.C.B. Schopen, M.H.P.W. Visker, P.D. Koks, E. Mullaart, J.A.M. van Arendonk, H. Bovenhuis

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83 Citations (Scopus)


Our objective was to perform a genome-wide association study for content in bovine milk of aS1-casein (aS1-CN), aS2-casein (aS2-CN), ß-casein (ß-CN), ¿-casein (¿-CN), a-lactalbumin (a-LA), ß-lactoglobulin (ß-LG), casein index, protein percentage, and protein yield using a 50K single nucleotide polymorphism (SNP) chip. In total, 1,713 Dutch Holstein-Friesian cows were genotyped for 50,228 SNP and a 2-step association study was performed. The first step involved a general linear model and the second step used a mixed model accounting for all family relationships. Associations with milk protein content and composition were detected on 20 bovine autosomes. The main genomic regions associated with milk protein composition or protein percentage were found on chromosomes 5, 6, 11, and 14. The number of chromosomal regions showing significant (false discovery rate
Original languageEnglish
Pages (from-to)3148-3158
JournalJournal of Dairy Science
Issue number6
Publication statusPublished - 2011


  • quantitative trait loci
  • genetic-polymorphism
  • beta-lactoglobulin
  • missense mutation
  • alpha-lactalbumin
  • multiple levels
  • mixed-model
  • bovine-milk
  • casein
  • yield


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