Whole brain transcriptomics of intermittently fed individuals of the marine teleost Sparus aurata

O. Ntantali*, E.E. Malandrakis, W. Abbink, E. Golomazou, I.T. Karapanagiotidis, H. Miliou, P. Panagiotaki

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A major challenge in fish physiology is to understand the mechanisms underlying the transcriptomic responses of fish brain to food deprivation. Differential gene expression analysis identified in total 2240 transcripts that presented >2-fold change (adjusted p < 0.01) between each treatment and the control group (C). The identity of the transcripts was obtained with annotation against multiple public databases and they were grouped according to their expression patterns. The gene ontology terms that were substantially affected were identified by functional annotation analysis. Genes related to ion transport, cell cycle and cell adhesion were mainly regulated during fasting and refeeding. These findings contribute to identify key indicators for the molecular basis of brain functions during periods of starvation in gilthead seabream.

Original languageEnglish
Article number100737
JournalComparative Biochemistry and Physiology - Part D: Genomics and Proteomics
Volume36
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Brain transcriptome
  • Intermittent feeding
  • Ion transport
  • RNA-seq

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