Waves of change: immunomodulation of the innate immune response by low frequency electromagnetic field exposure

L.A. Golbach

Research output: Thesisinternal PhD, WU

Abstract

 

In this thesis we investigated possible modulatory roles of low frequency electromagnetic fields (LF EMFs) exposure on the innate immune system. Recent decades have seen a huge increase in the use of electronic devices that nowadays enable us to communicate with distant family, enjoy music everywhere or order food without leaving the house. However besides the benefits, this evolution has also resulted in increased public concern about the potential adverse health effects of non-ionizing radiation. Every power line or electronic device emits a wide range of electromagnetic waves, which can pass through our bodies or damage our skin, depending on the characteristics of the waves. The symptoms attributed to continuous EMF exposure range from non-specific physical symptoms, such as fatigue 1, headaches 2, and redness of the skin to increased prevalence of childhood leukaemia 3. Although many theories regarding a potential mechanism of induction are put forward, to date no clear mechanism of action has been elucidated. Experimental evidence that could support an association between exposure and health status appears to be insufficient and inconsistent 4,5. We investigated the potential effect of LF EMF exposure on neutrophils, one of the key players of the innate immune response. We tried to elucidate a possible mechanism of interaction between intracellular signalling pathways and LF EMF exposure. We aimed to investigate calcium signalling, actin reorganization, cell migration and antimicrobial activity during exposure with different in vitro approaches.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Savelkoul, Huub, Promotor
  • van Kemenade, Lidy, Co-promotor
Award date18 Sep 2015
Place of PublicationWageningen
Publisher
Print ISBNs9789462574090
Publication statusPublished - 2015

Fingerprint

Electromagnetic Fields
Immunomodulation
Innate Immunity
Nonionizing Radiation
Electromagnetic Radiation
Equipment and Supplies
Skin
Calcium Signaling
Music
Health Status
Cell Movement
Fatigue
Headache
Actins
Immune System
Leukemia
Neutrophils
Food
Health

Keywords

  • immune response
  • electromagnetic field
  • cells
  • cellular biology
  • exposure

Cite this

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title = "Waves of change: immunomodulation of the innate immune response by low frequency electromagnetic field exposure",
abstract = "  In this thesis we investigated possible modulatory roles of low frequency electromagnetic fields (LF EMFs) exposure on the innate immune system. Recent decades have seen a huge increase in the use of electronic devices that nowadays enable us to communicate with distant family, enjoy music everywhere or order food without leaving the house. However besides the benefits, this evolution has also resulted in increased public concern about the potential adverse health effects of non-ionizing radiation. Every power line or electronic device emits a wide range of electromagnetic waves, which can pass through our bodies or damage our skin, depending on the characteristics of the waves. The symptoms attributed to continuous EMF exposure range from non-specific physical symptoms, such as fatigue 1, headaches 2, and redness of the skin to increased prevalence of childhood leukaemia 3. Although many theories regarding a potential mechanism of induction are put forward, to date no clear mechanism of action has been elucidated. Experimental evidence that could support an association between exposure and health status appears to be insufficient and inconsistent 4,5. We investigated the potential effect of LF EMF exposure on neutrophils, one of the key players of the innate immune response. We tried to elucidate a possible mechanism of interaction between intracellular signalling pathways and LF EMF exposure. We aimed to investigate calcium signalling, actin reorganization, cell migration and antimicrobial activity during exposure with different in vitro approaches.",
keywords = "immuniteitsreactie, elektromagnetisch veld, cellen, celbiologie, blootstelling, immune response, electromagnetic field, cells, cellular biology, exposure",
author = "L.A. Golbach",
note = "WU thesis 6131",
year = "2015",
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publisher = "Wageningen University",
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Golbach, LA 2015, 'Waves of change: immunomodulation of the innate immune response by low frequency electromagnetic field exposure', Doctor of Philosophy, Wageningen University, Wageningen.

Waves of change: immunomodulation of the innate immune response by low frequency electromagnetic field exposure. / Golbach, L.A.

Wageningen : Wageningen University, 2015. 172 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Waves of change: immunomodulation of the innate immune response by low frequency electromagnetic field exposure

AU - Golbach, L.A.

N1 - WU thesis 6131

PY - 2015

Y1 - 2015

N2 -   In this thesis we investigated possible modulatory roles of low frequency electromagnetic fields (LF EMFs) exposure on the innate immune system. Recent decades have seen a huge increase in the use of electronic devices that nowadays enable us to communicate with distant family, enjoy music everywhere or order food without leaving the house. However besides the benefits, this evolution has also resulted in increased public concern about the potential adverse health effects of non-ionizing radiation. Every power line or electronic device emits a wide range of electromagnetic waves, which can pass through our bodies or damage our skin, depending on the characteristics of the waves. The symptoms attributed to continuous EMF exposure range from non-specific physical symptoms, such as fatigue 1, headaches 2, and redness of the skin to increased prevalence of childhood leukaemia 3. Although many theories regarding a potential mechanism of induction are put forward, to date no clear mechanism of action has been elucidated. Experimental evidence that could support an association between exposure and health status appears to be insufficient and inconsistent 4,5. We investigated the potential effect of LF EMF exposure on neutrophils, one of the key players of the innate immune response. We tried to elucidate a possible mechanism of interaction between intracellular signalling pathways and LF EMF exposure. We aimed to investigate calcium signalling, actin reorganization, cell migration and antimicrobial activity during exposure with different in vitro approaches.

AB -   In this thesis we investigated possible modulatory roles of low frequency electromagnetic fields (LF EMFs) exposure on the innate immune system. Recent decades have seen a huge increase in the use of electronic devices that nowadays enable us to communicate with distant family, enjoy music everywhere or order food without leaving the house. However besides the benefits, this evolution has also resulted in increased public concern about the potential adverse health effects of non-ionizing radiation. Every power line or electronic device emits a wide range of electromagnetic waves, which can pass through our bodies or damage our skin, depending on the characteristics of the waves. The symptoms attributed to continuous EMF exposure range from non-specific physical symptoms, such as fatigue 1, headaches 2, and redness of the skin to increased prevalence of childhood leukaemia 3. Although many theories regarding a potential mechanism of induction are put forward, to date no clear mechanism of action has been elucidated. Experimental evidence that could support an association between exposure and health status appears to be insufficient and inconsistent 4,5. We investigated the potential effect of LF EMF exposure on neutrophils, one of the key players of the innate immune response. We tried to elucidate a possible mechanism of interaction between intracellular signalling pathways and LF EMF exposure. We aimed to investigate calcium signalling, actin reorganization, cell migration and antimicrobial activity during exposure with different in vitro approaches.

KW - immuniteitsreactie

KW - elektromagnetisch veld

KW - cellen

KW - celbiologie

KW - blootstelling

KW - immune response

KW - electromagnetic field

KW - cells

KW - cellular biology

KW - exposure

M3 - internal PhD, WU

SN - 9789462574090

PB - Wageningen University

CY - Wageningen

ER -