Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom pleurotus ostreatus (Agaricomycetes) with HMGCR inhibitory activity

Alicia Gil-Ramírez*, Fhernanda R. Smiderle, Diego Morales, Coen Govers, Andriy Synytsya, Harry J. Wichers, Marcello Iacomini, Cristina Soler-Rivas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly β-glucans, mannogalactans, and glycogen (e.g., α-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more β-(1→3)-glucans than β-(1→3),(1→6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.
Original languageEnglish
Pages (from-to)879-892
JournalInternational Journal of Medicinal Mushrooms
Volume19
Issue number10
DOIs
Publication statusPublished - 2017

Keywords

  • Caco2
  • Cholesterol
  • HMGCR
  • Medicinal mushrooms
  • Pleurotus ostreatus
  • Polysaccharides
  • β-glucans

Fingerprint Dive into the research topics of 'Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom pleurotus ostreatus (Agaricomycetes) with HMGCR inhibitory activity'. Together they form a unique fingerprint.

Cite this