Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion

Stefanie Sieste, Thomas Mack, Christopher V. Synatschke, Corinna Schilling, Christopher Meyer zu Reckendorf, Laura Pendi, Sean Harvey, Francesco S. Ruggeri, Tuomas P.J. Knowles, Christoph Meier, David Y.W. Ng, Tanja Weil*, Bernd Knöll

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Abstract

Hybrid nanomaterials have shown great potential in regenerative medicine due to the unique opportunities to customize materials properties for effectively controlling cellular growth. The peptide nanofiber-mediated auto-oxidative polymerization of dopamine, resulting in stable aqueous dispersions of polydopamine-coated peptide hybrid nanofibers, is demonstrated. The catechol residues of the polydopamine coating on the hybrid nanofibers are accessible and provide a platform for introducing functionalities in a pH-responsive polymer analogous reaction, which is demonstrated using a boronic acid modified fluorophore. The resulting hybrid nanofibers exhibit attractive properties in their cellular interactions: they enhance neuronal cell adhesion, nerve fiber growth, and growth cone area, thus providing great potential in regenerative medicine. Furthermore, the facile modification by pH-responsive supramolecular polymer analog reactions allows tailoring the functional properties of the hybrid nanofibers in a reversible fashion.
Original languageEnglish
Article number1701485
JournalAdvanced Healthcare Materials
Volume7
Issue number11
DOIs
Publication statusPublished - 6 Jun 2018
Externally publishedYes

Keywords

  • amyloid fibers
  • hybrid nanomaterial
  • neuronal growth
  • peptide nanofibers
  • polydopamine coating

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