TY - JOUR
T1 - Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
AU - Sieste, Stefanie
AU - Mack, Thomas
AU - Synatschke, Christopher V.
AU - Schilling, Corinna
AU - Meyer zu Reckendorf, Christopher
AU - Pendi, Laura
AU - Harvey, Sean
AU - Ruggeri, Francesco S.
AU - Knowles, Tuomas P.J.
AU - Meier, Christoph
AU - Ng, David Y.W.
AU - Weil, Tanja
AU - Knöll, Bernd
PY - 2018/6/6
Y1 - 2018/6/6
N2 - Hybrid nanomaterials have shown great potential in regenerative medicine due to the unique opportunities to customize materials properties for effectively controlling cellular growth. The peptide nanofiber-mediated auto-oxidative polymerization of dopamine, resulting in stable aqueous dispersions of polydopamine-coated peptide hybrid nanofibers, is demonstrated. The catechol residues of the polydopamine coating on the hybrid nanofibers are accessible and provide a platform for introducing functionalities in a pH-responsive polymer analogous reaction, which is demonstrated using a boronic acid modified fluorophore. The resulting hybrid nanofibers exhibit attractive properties in their cellular interactions: they enhance neuronal cell adhesion, nerve fiber growth, and growth cone area, thus providing great potential in regenerative medicine. Furthermore, the facile modification by pH-responsive supramolecular polymer analog reactions allows tailoring the functional properties of the hybrid nanofibers in a reversible fashion.
AB - Hybrid nanomaterials have shown great potential in regenerative medicine due to the unique opportunities to customize materials properties for effectively controlling cellular growth. The peptide nanofiber-mediated auto-oxidative polymerization of dopamine, resulting in stable aqueous dispersions of polydopamine-coated peptide hybrid nanofibers, is demonstrated. The catechol residues of the polydopamine coating on the hybrid nanofibers are accessible and provide a platform for introducing functionalities in a pH-responsive polymer analogous reaction, which is demonstrated using a boronic acid modified fluorophore. The resulting hybrid nanofibers exhibit attractive properties in their cellular interactions: they enhance neuronal cell adhesion, nerve fiber growth, and growth cone area, thus providing great potential in regenerative medicine. Furthermore, the facile modification by pH-responsive supramolecular polymer analog reactions allows tailoring the functional properties of the hybrid nanofibers in a reversible fashion.
KW - amyloid fibers
KW - hybrid nanomaterial
KW - neuronal growth
KW - peptide nanofibers
KW - polydopamine coating
U2 - 10.1002/adhm.201701485
DO - 10.1002/adhm.201701485
M3 - Article
C2 - 29635761
AN - SCOPUS:85045214873
SN - 2192-2640
VL - 7
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 11
M1 - 1701485
ER -