Vitamin D status is associated with physical performance: the results of three independent cohorts

E. Sohl, R.T. de Jongh, A.C. Heijboer, K.M.A. Swart, E.M. Brouwer, A.W. Enneman, C.P.G.M. de Groot, N. van der Velde, R.A.M. Dhonukshe-Rutten, P. Lips, N.M. van Schoor

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Abstract

This study, on the association between vitamin D status and physical performance and its decline, shows that vitamin D status is associated with physical performance in several older age groups. However, vitamin D status does not predict a decline in physical performance in individuals aged 55-65 years. Previous research in the Longitudinal Aging Study Amsterdam (LASA) showed an association of vitamin D status with physical performance and its decline in persons aged 65 years and older. The current study aims to determine these associations in younger individuals and to replicate previous research of LASA. Data from three independent cohorts were used: two cohorts of LASA (LASA-II with measurements in 2002 (n = 707) and 2009 (n = 491), LASA-I-2009 (n = 355)) and the baseline measurement of the B-Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) study (n = 2,813). Participants performed three tests (walking test, chair stands, and tandem stand; range total score 0-12), except in LASA-II-2002 (only walking and chair stands tests; range total score 0-8). Multiple linear and logistic regression were used to assess whether vitamin D status was associated with total physical performance and its decline, respectively. The mean age of the participants was 60.0 (SD 3.0), 65.9 (2.9), 78.4 (5.3), and 74.4 (6.8) years for LASA-II-2002, LASA-II-2009, LASA-I-2009, and B-PROOF, respectively. Vitamin D status was not predictive of a clinical decline in total physical performance score in the LASA-II-2002 cohort (aged 55-65 years). After adjustment for confounding, participants with serum 25(OH)D <50 nmol/L scored 0.8 (95 % confidence interval 0.4-1.2), 0.9 (0.3-1.5), 1.5 (0.8-2.3), and 0.6 (0.3-0.9) points lower on total physical performance than participants with serum 25(OH)D a parts per thousand yenaEuro parts per thousand 75 nmol/L. Our study confirmed that serum 25(OH)D is associated with physical performance. However, vitamin D status did not predict a clinical decline in physical performance in individuals aged 55-65 years.
Original languageEnglish
Pages (from-to)187-196
JournalOsteoporis International
Volume24
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Vitamin D
Longitudinal Studies
Vitamin B Complex
Osteoporotic Fractures
Walking
Serum
Research
Linear Models
Age Groups
Logistic Models
Confidence Intervals

Keywords

  • older-adults
  • 25-hydroxyvitamin d
  • d supplementation
  • muscle strength
  • meaningful change
  • d deficiency
  • disability
  • fractures
  • women
  • amsterdam

Cite this

Sohl, E., de Jongh, R. T., Heijboer, A. C., Swart, K. M. A., Brouwer, E. M., Enneman, A. W., ... van Schoor, N. M. (2013). Vitamin D status is associated with physical performance: the results of three independent cohorts. Osteoporis International, 24(1), 187-196. https://doi.org/10.1007/s00198-012-2124-5
Sohl, E. ; de Jongh, R.T. ; Heijboer, A.C. ; Swart, K.M.A. ; Brouwer, E.M. ; Enneman, A.W. ; de Groot, C.P.G.M. ; van der Velde, N. ; Dhonukshe-Rutten, R.A.M. ; Lips, P. ; van Schoor, N.M. / Vitamin D status is associated with physical performance: the results of three independent cohorts. In: Osteoporis International. 2013 ; Vol. 24, No. 1. pp. 187-196.
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Sohl, E, de Jongh, RT, Heijboer, AC, Swart, KMA, Brouwer, EM, Enneman, AW, de Groot, CPGM, van der Velde, N, Dhonukshe-Rutten, RAM, Lips, P & van Schoor, NM 2013, 'Vitamin D status is associated with physical performance: the results of three independent cohorts', Osteoporis International, vol. 24, no. 1, pp. 187-196. https://doi.org/10.1007/s00198-012-2124-5

Vitamin D status is associated with physical performance: the results of three independent cohorts. / Sohl, E.; de Jongh, R.T.; Heijboer, A.C.; Swart, K.M.A.; Brouwer, E.M.; Enneman, A.W.; de Groot, C.P.G.M.; van der Velde, N.; Dhonukshe-Rutten, R.A.M.; Lips, P.; van Schoor, N.M.

In: Osteoporis International, Vol. 24, No. 1, 2013, p. 187-196.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Vitamin D status is associated with physical performance: the results of three independent cohorts

AU - Sohl, E.

AU - de Jongh, R.T.

AU - Heijboer, A.C.

AU - Swart, K.M.A.

AU - Brouwer, E.M.

AU - Enneman, A.W.

AU - de Groot, C.P.G.M.

AU - van der Velde, N.

AU - Dhonukshe-Rutten, R.A.M.

AU - Lips, P.

AU - van Schoor, N.M.

PY - 2013

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N2 - This study, on the association between vitamin D status and physical performance and its decline, shows that vitamin D status is associated with physical performance in several older age groups. However, vitamin D status does not predict a decline in physical performance in individuals aged 55-65 years. Previous research in the Longitudinal Aging Study Amsterdam (LASA) showed an association of vitamin D status with physical performance and its decline in persons aged 65 years and older. The current study aims to determine these associations in younger individuals and to replicate previous research of LASA. Data from three independent cohorts were used: two cohorts of LASA (LASA-II with measurements in 2002 (n = 707) and 2009 (n = 491), LASA-I-2009 (n = 355)) and the baseline measurement of the B-Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) study (n = 2,813). Participants performed three tests (walking test, chair stands, and tandem stand; range total score 0-12), except in LASA-II-2002 (only walking and chair stands tests; range total score 0-8). Multiple linear and logistic regression were used to assess whether vitamin D status was associated with total physical performance and its decline, respectively. The mean age of the participants was 60.0 (SD 3.0), 65.9 (2.9), 78.4 (5.3), and 74.4 (6.8) years for LASA-II-2002, LASA-II-2009, LASA-I-2009, and B-PROOF, respectively. Vitamin D status was not predictive of a clinical decline in total physical performance score in the LASA-II-2002 cohort (aged 55-65 years). After adjustment for confounding, participants with serum 25(OH)D <50 nmol/L scored 0.8 (95 % confidence interval 0.4-1.2), 0.9 (0.3-1.5), 1.5 (0.8-2.3), and 0.6 (0.3-0.9) points lower on total physical performance than participants with serum 25(OH)D a parts per thousand yenaEuro parts per thousand 75 nmol/L. Our study confirmed that serum 25(OH)D is associated with physical performance. However, vitamin D status did not predict a clinical decline in physical performance in individuals aged 55-65 years.

AB - This study, on the association between vitamin D status and physical performance and its decline, shows that vitamin D status is associated with physical performance in several older age groups. However, vitamin D status does not predict a decline in physical performance in individuals aged 55-65 years. Previous research in the Longitudinal Aging Study Amsterdam (LASA) showed an association of vitamin D status with physical performance and its decline in persons aged 65 years and older. The current study aims to determine these associations in younger individuals and to replicate previous research of LASA. Data from three independent cohorts were used: two cohorts of LASA (LASA-II with measurements in 2002 (n = 707) and 2009 (n = 491), LASA-I-2009 (n = 355)) and the baseline measurement of the B-Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) study (n = 2,813). Participants performed three tests (walking test, chair stands, and tandem stand; range total score 0-12), except in LASA-II-2002 (only walking and chair stands tests; range total score 0-8). Multiple linear and logistic regression were used to assess whether vitamin D status was associated with total physical performance and its decline, respectively. The mean age of the participants was 60.0 (SD 3.0), 65.9 (2.9), 78.4 (5.3), and 74.4 (6.8) years for LASA-II-2002, LASA-II-2009, LASA-I-2009, and B-PROOF, respectively. Vitamin D status was not predictive of a clinical decline in total physical performance score in the LASA-II-2002 cohort (aged 55-65 years). After adjustment for confounding, participants with serum 25(OH)D <50 nmol/L scored 0.8 (95 % confidence interval 0.4-1.2), 0.9 (0.3-1.5), 1.5 (0.8-2.3), and 0.6 (0.3-0.9) points lower on total physical performance than participants with serum 25(OH)D a parts per thousand yenaEuro parts per thousand 75 nmol/L. Our study confirmed that serum 25(OH)D is associated with physical performance. However, vitamin D status did not predict a clinical decline in physical performance in individuals aged 55-65 years.

KW - older-adults

KW - 25-hydroxyvitamin d

KW - d supplementation

KW - muscle strength

KW - meaningful change

KW - d deficiency

KW - disability

KW - fractures

KW - women

KW - amsterdam

U2 - 10.1007/s00198-012-2124-5

DO - 10.1007/s00198-012-2124-5

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JO - Osteoporis International

JF - Osteoporis International

SN - 0937-941X

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ER -