Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients

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Abstract

Purpose: Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated. Methods: In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-sectional relationships of polypharmacy (≥5 medications concomitantly used), severe polypharmacy (≥10 medications), and use of twenty-one specific drug groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance. Results: Overall prevalence of polypharmacy was 65 %, of severe polypharmacy 22 %. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 % (

LanguageEnglish
Article number5
Pages605-614
JournalEuropean Journal of Clinical Pharmacology
DOIs
Publication statusPublished - 2016

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Polypharmacy
Vitamin D Deficiency
Drug-Related Side Effects and Adverse Reactions
Geriatrics
Outpatients
Cross-Sectional Studies
Vitamin D
Pharmaceutical Preparations
Independent Living
Public Health
Serum
Population

Keywords

  • Adverse drug reaction
  • Drug-food interaction
  • Elderly
  • Polypharmacy
  • Vitamin D

Cite this

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title = "Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients",
abstract = "Purpose: Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated. Methods: In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-sectional relationships of polypharmacy (≥5 medications concomitantly used), severe polypharmacy (≥10 medications), and use of twenty-one specific drug groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance. Results: Overall prevalence of polypharmacy was 65 {\%}, of severe polypharmacy 22 {\%}. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 {\%} (",
keywords = "Adverse drug reaction, Drug-food interaction, Elderly, Polypharmacy, Vitamin D",
author = "{van Orten-Luiten}, A.C.B. and A. Janse and R.A.M. Dhonukshe-Rutten and R.F. Witkamp",
year = "2016",
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language = "English",
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journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer Verlag",

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TY - JOUR

T1 - Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients

AU - van Orten-Luiten, A.C.B.

AU - Janse, A.

AU - Dhonukshe-Rutten, R.A.M.

AU - Witkamp, R.F.

PY - 2016

Y1 - 2016

N2 - Purpose: Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated. Methods: In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-sectional relationships of polypharmacy (≥5 medications concomitantly used), severe polypharmacy (≥10 medications), and use of twenty-one specific drug groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance. Results: Overall prevalence of polypharmacy was 65 %, of severe polypharmacy 22 %. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 % (

AB - Purpose: Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated. Methods: In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-sectional relationships of polypharmacy (≥5 medications concomitantly used), severe polypharmacy (≥10 medications), and use of twenty-one specific drug groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance. Results: Overall prevalence of polypharmacy was 65 %, of severe polypharmacy 22 %. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 % (

KW - Adverse drug reaction

KW - Drug-food interaction

KW - Elderly

KW - Polypharmacy

KW - Vitamin D

U2 - 10.1007/s00228-016-2016-2

DO - 10.1007/s00228-016-2016-2

M3 - Article

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EP - 614

JO - European Journal of Clinical Pharmacology

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