Vitamin D binding protein (VDBP) and its gene polymorphisms—the risk of malignant tumors and other diseases

Dominika Rozmus, Alicja Ciesielska, Janusz Płomiński, Roman Grzybowski, Ewa Fiedorowicz, Natalia Kordulewska, Huub Savelkoul, Elżbieta Kostyra, Anna Cieślińska*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Vitamin D is an important component of the endocrine system that controls calcium homeostasis and bone mineralization. Because of the very short half‐life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP). The most common polymorphisms: rs4588 and rs7041 in the vitamin D binding protein gene may correlate with differences in vitamin D status in the serum. This review presents data that relate to the presence of genetic variants in the VDBP gene in correlation with certain diseases, mostly concerning cancers (breast, prostate, pancreatic, lung, colorectal, basal cell carcinoma cancer and cutaneous melanoma) or other related diseases (thyroid autoimmunity disorders, obesity, diabetes mellitus, bone metabolism, rheumatoid arthritis, ankylosing spondylitis, asthma, chronic obstructive pulmonary disease, tuberculosis and coronary artery diseases).

Original languageEnglish
Article number7822
JournalInternational Journal of Molecular Sciences
Volume21
Issue number21
DOIs
Publication statusPublished - 22 Oct 2020

Keywords

  • Cancer
  • Single nucleotide polymorphism
  • SNP
  • VDBP
  • Vitamin D
  • Vitamin D binding protein
  • [25(OH)D]

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