Vitamin B12 requirements in older adults

Esmee Doets; C.P.G.M. de Groot

doi:10.1016/B978-0-12-801816-3.00042-X

Vitamin B12 requirements in older adults

Esmee Doets, C.P.G.M. de Groot

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

1 Citation (Scopus)

Abstract

This paper provides an overview of dose-response evidence relevant for estimating vitamin B12 requirements of healthy adults and elderly people, considering different indicators of health: vitamin B12 body stores, cognitive function, bone health, and biomarkers of vitamin B12 status.

Vitamin B12 intakes needed to compensate daily losses may range from 3.8 to 20.7 μg/day depending on the assumptions used. The current evidence-base on cognitive function and bone health is too limited to estimate vitamin B12 requirements. Evidence from controlled trials and observational studies on vitamin B12 intake and biomarkers of vitamin B12 status provided estimates of average requirements between 0.07 and 4.1 μg/day, depending on the type of data and selected cut-off value indicating adequate vitamin B12 status. To improve estimates of requirements, advanced models for integrating the evidence are needed with assumptions consistent with the strengths and limitations of epidemiological and physiological studies.

Original language	English
Title of host publication	Molecular Basis of Nutrition and Aging
Editors	Marco Malavolta, Eugenio Mocchegiani
Publisher	Elsevier
Pages	599-607
ISBN (Print)	9780128018163
DOIs	https://doi.org/10.1016/B978-0-12-801816-3.00042-X
Publication status	Published - 26 May 2016

Keywords

EURRECA
Micronutrient recommendations
Requirements
Systematic review
Vitamin B12

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10.1016/B978-0-12-801816-3.00042-X

Cite this

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abstract = "This paper provides an overview of dose-response evidence relevant for estimating vitamin B12 requirements of healthy adults and elderly people, considering different indicators of health: vitamin B12 body stores, cognitive function, bone health, and biomarkers of vitamin B12 status.Vitamin B12 intakes needed to compensate daily losses may range from 3.8 to 20.7 μg/day depending on the assumptions used. The current evidence-base on cognitive function and bone health is too limited to estimate vitamin B12 requirements. Evidence from controlled trials and observational studies on vitamin B12 intake and biomarkers of vitamin B12 status provided estimates of average requirements between 0.07 and 4.1 μg/day, depending on the type of data and selected cut-off value indicating adequate vitamin B12 status. To improve estimates of requirements, advanced models for integrating the evidence are needed with assumptions consistent with the strengths and limitations of epidemiological and physiological studies.",

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AB - This paper provides an overview of dose-response evidence relevant for estimating vitamin B12 requirements of healthy adults and elderly people, considering different indicators of health: vitamin B12 body stores, cognitive function, bone health, and biomarkers of vitamin B12 status.Vitamin B12 intakes needed to compensate daily losses may range from 3.8 to 20.7 μg/day depending on the assumptions used. The current evidence-base on cognitive function and bone health is too limited to estimate vitamin B12 requirements. Evidence from controlled trials and observational studies on vitamin B12 intake and biomarkers of vitamin B12 status provided estimates of average requirements between 0.07 and 4.1 μg/day, depending on the type of data and selected cut-off value indicating adequate vitamin B12 status. To improve estimates of requirements, advanced models for integrating the evidence are needed with assumptions consistent with the strengths and limitations of epidemiological and physiological studies.

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KW - Micronutrient recommendations

KW - Requirements

KW - Systematic review

KW - Vitamin B12

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Vitamin B12 requirements in older adults

Abstract

Keywords

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