Vitamin B12 in Relation to Oxidative Stress: A Systematic Review

Erik E. van de Lagemaat, C.P.G.M. de Groot, Ellen G.H.M. van den Heuvel

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

The triage theory posits that modest micronutrient deficiencies may induce reallocation ofnutrients to processes necessary for immediate survival at the expense of long-term health. Neglectedprocesses could in time contribute to the onset of age-related diseases, in which oxidative stress isbelieved to be a major factor. Vitamin B12 (B12) appears to possess antioxidant properties. This reviewaims to summarise the potential antioxidant mechanisms of B12 and investigate B12 status in relationto oxidative stress markers. A systematic query-based search of PubMed was performed to identifyeligible publications. The potential antioxidant properties of B12 include: (1) direct scavenging ofreactive oxygen species (ROS), particularly superoxide; (2) indirect stimulation of ROS scavengingby preservation of glutathione; (3) modulation of cytokine and growth factor production to offerprotection from immune response-induced oxidative stress; (4) reduction of homocysteine-inducedoxidative stress; and (5) reduction of oxidative stress caused by advanced glycation end products.Some evidence appears to suggest that lower B12 status is related to increased pro-oxidant anddecreased antioxidant status, both overall and for subclinically deficient individuals compared tothose with normal B12 status. However, there is a lack of randomised controlled trials and prospectivestudies focusing specifically on the relation between B12 and oxidative stress in humans, resulting ina low strength of evidence. Further work is warranted.
LanguageEnglish
Article number482
JournalNutrients
Volume11
Issue number2
DOIs
Publication statusPublished - 25 Feb 2019

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systematic review
vitamin B12
Vitamin B 12
Oxidative Stress
oxidative stress
Antioxidants
antioxidants
Advanced Glycosylation End Products
Triage
Micronutrients
homocysteine
production economics
Homocysteine
Age of Onset
PubMed
oxidants
Superoxides
superoxide anion
growth factors
Glutathione

Cite this

van de Lagemaat, Erik E. ; de Groot, C.P.G.M. ; van den Heuvel, Ellen G.H.M. / Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. In: Nutrients. 2019 ; Vol. 11, No. 2.
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abstract = "The triage theory posits that modest micronutrient deficiencies may induce reallocation ofnutrients to processes necessary for immediate survival at the expense of long-term health. Neglectedprocesses could in time contribute to the onset of age-related diseases, in which oxidative stress isbelieved to be a major factor. Vitamin B12 (B12) appears to possess antioxidant properties. This reviewaims to summarise the potential antioxidant mechanisms of B12 and investigate B12 status in relationto oxidative stress markers. A systematic query-based search of PubMed was performed to identifyeligible publications. The potential antioxidant properties of B12 include: (1) direct scavenging ofreactive oxygen species (ROS), particularly superoxide; (2) indirect stimulation of ROS scavengingby preservation of glutathione; (3) modulation of cytokine and growth factor production to offerprotection from immune response-induced oxidative stress; (4) reduction of homocysteine-inducedoxidative stress; and (5) reduction of oxidative stress caused by advanced glycation end products.Some evidence appears to suggest that lower B12 status is related to increased pro-oxidant anddecreased antioxidant status, both overall and for subclinically deficient individuals compared tothose with normal B12 status. However, there is a lack of randomised controlled trials and prospectivestudies focusing specifically on the relation between B12 and oxidative stress in humans, resulting ina low strength of evidence. Further work is warranted.",
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Vitamin B12 in Relation to Oxidative Stress: A Systematic Review. / van de Lagemaat, Erik E.; de Groot, C.P.G.M.; van den Heuvel, Ellen G.H.M.

In: Nutrients, Vol. 11, No. 2, 482, 25.02.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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