Virulence of Newcastle disease virus: what is known so far?

J.C.F.M. Dortmans, G. Koch, P.J.M. Rottier, B.P.H. Peeters

Research output: Contribution to journalArticleAcademicpeer-review

132 Citations (Scopus)

Abstract

In the last decade many studies have been performed on the virulence of Newcastle disease virus (NDV). This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors
Original languageEnglish
Article number122
Number of pages11
JournalVeterinary Research
Volume42
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • hemagglutinin-neuraminidase protein
  • vesicular stomatitis-virus
  • strand rna viruses
  • paramyxovirus-v-proteins
  • pigeon pmv-1 viruses
  • influenza-a virus
  • fusion protein
  • cleavage-site
  • matrix protein
  • nucleotide-sequence

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