Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants

K.H. van Boeijen; P.G. Casey; C. Hill; R. Moezelaar; M.H. Zwietering; C.G.M. Gahan; T. Abee

doi:10.1016/j.micpath.2013.04.007

Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants

K.H. van Boeijen
, P.G. Casey
, C. Hill
, R. Moezelaar
, M.H. Zwietering
, C.G.M. Gahan
, T. Abee

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

High pressure treatment is a novel food processing approach for reducing pathogens in foods and food ingredients. However, relatively little is known about the pathogenic potential of organisms that survive the treatment. Twelve previously isolated and characterized variants of Listeria monocytogenes LO28 obtained after a high pressure treatment were assessed for their virulence potential and antibiotic susceptibility. Ten variants showed attenuated virulence while two variants retained full virulence in a mouse model of infection. Seven of the attenuated variants demonstrated a reduction in virulence factor activity. Compared to the wild type, all variants exhibited similar or increased susceptibility to multiple antibiotics commonly used in listeriosis treatment. Keywords: High hydrostatic pressure; Mouse model; Diversity; Pathogenicity; Antibiotics; CtsR

Original language	English
Pages (from-to)	48-51
Journal	Microbial Pathogenesis
Volume	59-60
DOIs	https://doi.org/10.1016/j.micpath.2013.04.007
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

high hydrostatic-pressure
ctsr
stress
kinetics
environment
strains
scott
acid
food

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10.1016/j.micpath.2013.04.007

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title = "Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants",

abstract = "High pressure treatment is a novel food processing approach for reducing pathogens in foods and food ingredients. However, relatively little is known about the pathogenic potential of organisms that survive the treatment. Twelve previously isolated and characterized variants of Listeria monocytogenes LO28 obtained after a high pressure treatment were assessed for their virulence potential and antibiotic susceptibility. Ten variants showed attenuated virulence while two variants retained full virulence in a mouse model of infection. Seven of the attenuated variants demonstrated a reduction in virulence factor activity. Compared to the wild type, all variants exhibited similar or increased susceptibility to multiple antibiotics commonly used in listeriosis treatment. Keywords: High hydrostatic pressure; Mouse model; Diversity; Pathogenicity; Antibiotics; CtsR",

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doi = "10.1016/j.micpath.2013.04.007",

language = "English",

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TY - JOUR

T1 - Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants

AU - van Boeijen, K.H.

AU - Casey, P.G.

AU - Hill, C.

AU - Moezelaar, R.

AU - Zwietering, M.H.

AU - Gahan, C.G.M.

AU - Abee, T.

PY - 2013

Y1 - 2013

N2 - High pressure treatment is a novel food processing approach for reducing pathogens in foods and food ingredients. However, relatively little is known about the pathogenic potential of organisms that survive the treatment. Twelve previously isolated and characterized variants of Listeria monocytogenes LO28 obtained after a high pressure treatment were assessed for their virulence potential and antibiotic susceptibility. Ten variants showed attenuated virulence while two variants retained full virulence in a mouse model of infection. Seven of the attenuated variants demonstrated a reduction in virulence factor activity. Compared to the wild type, all variants exhibited similar or increased susceptibility to multiple antibiotics commonly used in listeriosis treatment. Keywords: High hydrostatic pressure; Mouse model; Diversity; Pathogenicity; Antibiotics; CtsR

AB - High pressure treatment is a novel food processing approach for reducing pathogens in foods and food ingredients. However, relatively little is known about the pathogenic potential of organisms that survive the treatment. Twelve previously isolated and characterized variants of Listeria monocytogenes LO28 obtained after a high pressure treatment were assessed for their virulence potential and antibiotic susceptibility. Ten variants showed attenuated virulence while two variants retained full virulence in a mouse model of infection. Seven of the attenuated variants demonstrated a reduction in virulence factor activity. Compared to the wild type, all variants exhibited similar or increased susceptibility to multiple antibiotics commonly used in listeriosis treatment. Keywords: High hydrostatic pressure; Mouse model; Diversity; Pathogenicity; Antibiotics; CtsR

KW - high hydrostatic-pressure

KW - ctsr

KW - stress

KW - kinetics

KW - environment

KW - strains

KW - scott

KW - acid

KW - food

U2 - 10.1016/j.micpath.2013.04.007

DO - 10.1016/j.micpath.2013.04.007

M3 - Article

SN - 0882-4010

VL - 59-60

SP - 48

EP - 51

JO - Microbial Pathogenesis

JF - Microbial Pathogenesis

ER -

Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants

Abstract

UN SDGs

Keywords

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