Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages.

I.F.A. van der Linden, J.J.M. Voermans, E.M. van der Linde-Bril, A.T.J. Bianchi, P.J.G.M. Steverink

    Research output: Contribution to journalArticleAcademicpeer-review

    35 Citations (Scopus)

    Abstract

    The objective of this study was to measure the effect of two variables (pig age and virus strain) on selected responses (clinical signs, viraemia, virus excretion and seroconversion) of pigs following exposure to porcine reproductive and respiratory syndrome (PRRS) virus. Therefore, young (6 till 8 weeks old) and old (6 months old) pigs were infected with 3 different PRRSV strains, i.e. LV ter Huurne (LVTH), LV4.2.1 and SDSU#73. Regardless of the strain used for exposure, young pigs were more susceptible to infection as shown by a higher number of viraemic and virus excreting pigs. Strain differences were also evident. LV ter Huurne induced virus excretion in a higher number of pigs and with a higher virus titre, whereas SDSU#73 induced most severe clinical signs. LV4.2.1 induced viraemia and virus excretion in a low number of pigs. The kinetics of the antibody response differed per virus strain. The results presented here are useful in developing a less expensive standardised infection model, consisting of young pigs intranasally infected with a virulent PRRSV strain, to study the efficacy of new vaccine strains.
    Original languageEnglish
    Pages (from-to)1952-1957
    JournalVaccine
    Volume21
    Issue number17-18
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Porcine respiratory and reproductive syndrome virus
    Porcine reproductive and respiratory syndrome virus
    Virus Diseases
    Swine
    immune response
    kinetics
    swine
    Viruses
    infection
    viruses
    excretion
    Viremia
    viremia
    strain differences
    biological resistance
    seroconversion
    viral load
    Infection
    Viral Load
    Antibody Formation

    Keywords

    • serotype prrsv vaccine
    • aujeszkys disease
    • lelystad-virus
    • strains
    • swine
    • challenge
    • american

    Cite this

    van der Linden, I. F. A., Voermans, J. J. M., van der Linde-Bril, E. M., Bianchi, A. T. J., & Steverink, P. J. G. M. (2003). Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages. Vaccine, 21(17-18), 1952-1957. https://doi.org/10.1016/S0264-410X(02)00822-8
    van der Linden, I.F.A. ; Voermans, J.J.M. ; van der Linde-Bril, E.M. ; Bianchi, A.T.J. ; Steverink, P.J.G.M. / Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages. In: Vaccine. 2003 ; Vol. 21, No. 17-18. pp. 1952-1957.
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    abstract = "The objective of this study was to measure the effect of two variables (pig age and virus strain) on selected responses (clinical signs, viraemia, virus excretion and seroconversion) of pigs following exposure to porcine reproductive and respiratory syndrome (PRRS) virus. Therefore, young (6 till 8 weeks old) and old (6 months old) pigs were infected with 3 different PRRSV strains, i.e. LV ter Huurne (LVTH), LV4.2.1 and SDSU#73. Regardless of the strain used for exposure, young pigs were more susceptible to infection as shown by a higher number of viraemic and virus excreting pigs. Strain differences were also evident. LV ter Huurne induced virus excretion in a higher number of pigs and with a higher virus titre, whereas SDSU#73 induced most severe clinical signs. LV4.2.1 induced viraemia and virus excretion in a low number of pigs. The kinetics of the antibody response differed per virus strain. The results presented here are useful in developing a less expensive standardised infection model, consisting of young pigs intranasally infected with a virulent PRRSV strain, to study the efficacy of new vaccine strains.",
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    van der Linden, IFA, Voermans, JJM, van der Linde-Bril, EM, Bianchi, ATJ & Steverink, PJGM 2003, 'Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages.', Vaccine, vol. 21, no. 17-18, pp. 1952-1957. https://doi.org/10.1016/S0264-410X(02)00822-8

    Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages. / van der Linden, I.F.A.; Voermans, J.J.M.; van der Linde-Bril, E.M.; Bianchi, A.T.J.; Steverink, P.J.G.M.

    In: Vaccine, Vol. 21, No. 17-18, 2003, p. 1952-1957.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Voermans, J.J.M.

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    AU - Steverink, P.J.G.M.

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    AB - The objective of this study was to measure the effect of two variables (pig age and virus strain) on selected responses (clinical signs, viraemia, virus excretion and seroconversion) of pigs following exposure to porcine reproductive and respiratory syndrome (PRRS) virus. Therefore, young (6 till 8 weeks old) and old (6 months old) pigs were infected with 3 different PRRSV strains, i.e. LV ter Huurne (LVTH), LV4.2.1 and SDSU#73. Regardless of the strain used for exposure, young pigs were more susceptible to infection as shown by a higher number of viraemic and virus excreting pigs. Strain differences were also evident. LV ter Huurne induced virus excretion in a higher number of pigs and with a higher virus titre, whereas SDSU#73 induced most severe clinical signs. LV4.2.1 induced viraemia and virus excretion in a low number of pigs. The kinetics of the antibody response differed per virus strain. The results presented here are useful in developing a less expensive standardised infection model, consisting of young pigs intranasally infected with a virulent PRRSV strain, to study the efficacy of new vaccine strains.

    KW - serotype prrsv vaccine

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    KW - lelystad-virus

    KW - strains

    KW - swine

    KW - challenge

    KW - american

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    DO - 10.1016/S0264-410X(02)00822-8

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