Substantial improvements of agricultural systems are necessary to meet the future requirements of humanity. However, current agricultural knowledge and information systems are generally not well suited to meet the necessary improvements in productivity and sustainability. For more effective application of research output, research producers and research consumers should not be considered as separate individuals in the knowledge chain but as collaborating partners creating synergy. The current paper investigates the relationships between scientists and stakeholders and identifies approaches to increase the effectiveness of their communication. On-farm research has proven to be an effective means of improving exploitation of research output at farm level because it connects all relevant partners in the process. Furthermore, pilot farms can act as an effective platform for communication and dissemination. Regional networks of pilot farms should be established and connected across regions.