Verteringsenzymen van insecten als doel voor plantaardige afweerstoffen

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    Proteases from the digestive system of insects are targets of plant defense: the plant produces protease inhibitors to eliminate them. These protease inhibitors are small proteins, which can also be applied in crop protection, for instance through techniques of genetic modification (GMO). However, a number of polyphagous insects, for example Helicoverpa spp., appear not to be affected by protease inhibitors. Being polyphagous, these insects are used to the presence of different natural protease inhibitors in their diet. This may explain why they have adapted and use a protease that cannot be inhibited by a range of protease inhibitors. This protease is homologous to proteases that are extremely sensitive to inhibitors, and we are seeking a molecular understanding of how this adapted protease can avoid being inhibited. Protease inhibitors do work against a number of non-polyphagous insects and also against insects like aphids and thrips, which usually avoid contact with protease inhibitors. Application in agriculture is therefore increasing
    Original languageDutch
    Pages (from-to)138-142
    JournalEntomologische Berichten
    Issue number6
    Publication statusPublished - 2003


    • enzymes
    • insect pests
    • proteinases
    • proteinase inhibitors
    • enzyme inhibitors
    • genetic engineering
    • adaptation

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