Venom allergen-like proteins in secretions of plant-parasitic nematodes activate and suppress extracellular plant immune receptors

Research output: Thesisinternal PhD, WU

Abstract

 

Parasitic worms threaten human, animal and plant health by infecting people, livestock and crops worldwide. Animals and plants share an anciently evolved innate immune system. Parasites modulate this immune system by secreting proteins to maintain their parasitic lifestyle. This thesis describes how venom-allergen-like proteins (VAPs) that both animal- and plant-parasitic nematodes release into their hosts, modulate host innate immunity. On the one hand we found that one particular secreted VAP from the potato cyst nematode can activate host defenses in tomato plants, opening an opportunity for plant breeders to generate novel nematode-resistant cultivars. We showed that plants make more efficiently use of their limited repertoire of immune receptors by guarding common virulence targets of multiple unrelated plant pathogens. While on the other hand, we describe how VAPs may be used by parasites to suppress the host defense responses mediated by extracellular immune receptors. In short, this fundamental study contributes to our understanding of the molecular basis of persistent infections by parasitic nematodes in plants and in animals.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Bakker, Jaap, Promotor
  • Smant, Geert, Co-promotor
  • Goverse, Aska, Co-promotor
Award date28 May 2014
Publisher
Print ISBNs9789461739193
Publication statusPublished - 2014

Fingerprint

protein secretion
venoms
plant parasitic nematodes
allergens
proteins
animal parasitic nematodes
parasites
plant health
cyst nematodes
plant breeders
helminths
animal health
plant pathogens
lifestyle
immune system
human health
animals
virulence
livestock
Nematoda

Keywords

  • plant parasitic nematodes
  • nematoda
  • receptors
  • venoms
  • proteins
  • secretion
  • immunity
  • modulation

Cite this

@phdthesis{a3436aa71fb94c5e8b4e0f554ec34c9f,
title = "Venom allergen-like proteins in secretions of plant-parasitic nematodes activate and suppress extracellular plant immune receptors",
abstract = "  Parasitic worms threaten human, animal and plant health by infecting people, livestock and crops worldwide. Animals and plants share an anciently evolved innate immune system. Parasites modulate this immune system by secreting proteins to maintain their parasitic lifestyle. This thesis describes how venom-allergen-like proteins (VAPs) that both animal- and plant-parasitic nematodes release into their hosts, modulate host innate immunity. On the one hand we found that one particular secreted VAP from the potato cyst nematode can activate host defenses in tomato plants, opening an opportunity for plant breeders to generate novel nematode-resistant cultivars. We showed that plants make more efficiently use of their limited repertoire of immune receptors by guarding common virulence targets of multiple unrelated plant pathogens. While on the other hand, we describe how VAPs may be used by parasites to suppress the host defense responses mediated by extracellular immune receptors. In short, this fundamental study contributes to our understanding of the molecular basis of persistent infections by parasitic nematodes in plants and in animals.",
keywords = "plantenparasitaire nematoden, nematoda, receptoren, vergiffen, eiwitten, secretie, immuniteit, modulatie, plant parasitic nematodes, nematoda, receptors, venoms, proteins, secretion, immunity, modulation",
author = "{Lozano Torres}, J.L.",
note = "WU thesis 5756",
year = "2014",
language = "English",
isbn = "9789461739193",
publisher = "Wageningen University",
school = "Wageningen University",

}

TY - THES

T1 - Venom allergen-like proteins in secretions of plant-parasitic nematodes activate and suppress extracellular plant immune receptors

AU - Lozano Torres, J.L.

N1 - WU thesis 5756

PY - 2014

Y1 - 2014

N2 -   Parasitic worms threaten human, animal and plant health by infecting people, livestock and crops worldwide. Animals and plants share an anciently evolved innate immune system. Parasites modulate this immune system by secreting proteins to maintain their parasitic lifestyle. This thesis describes how venom-allergen-like proteins (VAPs) that both animal- and plant-parasitic nematodes release into their hosts, modulate host innate immunity. On the one hand we found that one particular secreted VAP from the potato cyst nematode can activate host defenses in tomato plants, opening an opportunity for plant breeders to generate novel nematode-resistant cultivars. We showed that plants make more efficiently use of their limited repertoire of immune receptors by guarding common virulence targets of multiple unrelated plant pathogens. While on the other hand, we describe how VAPs may be used by parasites to suppress the host defense responses mediated by extracellular immune receptors. In short, this fundamental study contributes to our understanding of the molecular basis of persistent infections by parasitic nematodes in plants and in animals.

AB -   Parasitic worms threaten human, animal and plant health by infecting people, livestock and crops worldwide. Animals and plants share an anciently evolved innate immune system. Parasites modulate this immune system by secreting proteins to maintain their parasitic lifestyle. This thesis describes how venom-allergen-like proteins (VAPs) that both animal- and plant-parasitic nematodes release into their hosts, modulate host innate immunity. On the one hand we found that one particular secreted VAP from the potato cyst nematode can activate host defenses in tomato plants, opening an opportunity for plant breeders to generate novel nematode-resistant cultivars. We showed that plants make more efficiently use of their limited repertoire of immune receptors by guarding common virulence targets of multiple unrelated plant pathogens. While on the other hand, we describe how VAPs may be used by parasites to suppress the host defense responses mediated by extracellular immune receptors. In short, this fundamental study contributes to our understanding of the molecular basis of persistent infections by parasitic nematodes in plants and in animals.

KW - plantenparasitaire nematoden

KW - nematoda

KW - receptoren

KW - vergiffen

KW - eiwitten

KW - secretie

KW - immuniteit

KW - modulatie

KW - plant parasitic nematodes

KW - nematoda

KW - receptors

KW - venoms

KW - proteins

KW - secretion

KW - immunity

KW - modulation

M3 - internal PhD, WU

SN - 9789461739193

PB - Wageningen University

ER -