Vector independent transmission of the vector-borne bluetongue virus

M.T.W. van der Sluijs, A.J. de Smit, R.J.M. Moormann

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Bluetongue is an economically important disease of ruminants. The causative agent, Bluetongue virus (BTV), is mainly transmitted by insect vectors. This review focuses on vector-free BTV transmission, and its epizootic and economic consequences. Vector-free transmission can either be vertical, from dam to fetus, or horizontal via direct contract. For several BTV-serotypes, vertical (transplacental) transmission has been described, resulting in severe congenital malformations. Transplacental transmission had been mainly associated with live vaccine strains. Yet, the European BTV-8 strain demonstrated a high incidence of transplacental transmission in natural circumstances. The relevance of transplacental transmission for the epizootiology is considered limited, especially in enzootic areas. However, transplacental transmission can have a substantial economic impact due to the loss of progeny. Inactivated vaccines have demonstrated to prevent transplacental transmission. Vector-free horizontal transmission has also been demonstrated. Since direct horizontal transmission requires close contact of animals, it is considered only relevant for within-farm spreading of BTV. The genetic determinants which enable vector-free transmission are present in virus strains circulating in the field. More research into the genetic changes which enable vector-free transmission is essential to better evaluate the risks associated with outbreaks of new BTV serotypes and to design more appropriate control measures. Read More: http://informahealthcare.com/doi/abs/10.3109/1040841X.2013.879850
Original languageEnglish
Pages (from-to)57-64
JournalCritical Reviews in Microbiology
Volume42
Issue number2
DOIs
Publication statusPublished - 2016

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Bluetongue virus
Economics
Bluetongue
Insect Vectors
Genetic Research
Inactivated Vaccines
Ruminants
Contracts
Disease Outbreaks
Fetus
Vaccines
Viruses
Incidence

Cite this

van der Sluijs, M.T.W. ; de Smit, A.J. ; Moormann, R.J.M. / Vector independent transmission of the vector-borne bluetongue virus. In: Critical Reviews in Microbiology. 2016 ; Vol. 42, No. 2. pp. 57-64.
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Vector independent transmission of the vector-borne bluetongue virus. / van der Sluijs, M.T.W.; de Smit, A.J.; Moormann, R.J.M.

In: Critical Reviews in Microbiology, Vol. 42, No. 2, 2016, p. 57-64.

Research output: Contribution to journalArticleAcademicpeer-review

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