The invention relates to methods for producing a propagation- competent strain of a mutant Reoviridae virus, and to a propagation- competent strain of a mutant Reoviridae virus that is obtainable by a method of the invention. The invention further relates to a propagation-competent strain of a mutant Reoviridae virus, comprising a deletion of a genetic region that is relevant for propagation of the virus, and to a vaccine, comprising a propagation-competent strain of a mutant Reoviridae virus.
|Publication status||Published - 20 Nov 2014|
van Rijn, P. A., van Gennip, H. G. P., van de Water, S. G. P., & Feenstra, F. (2014). Vaccines for diseases caused by viruses of the family of Reoviridae. (Patent No. WO2014185784). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2014185784A1&KC=A1&FT=D&ND=3&date=20141120&DB=&locale=en_EP#