Vaccine-induced immunopathology during bovine respiratory syncytial virus infection: exploring the parameters of pathogenesis

A.F.G. Antonis, R.S. Schrijver, F.J. Daus, M. Steverink, N. Stockhofe, J.P. Langedijk, R.G. van der Most

    Research output: Contribution to journalArticleAcademicpeer-review

    71 Citations (Scopus)

    Abstract

    The bovine and human respiratory syncytial viruses cause severe lower respiratory tract infections. Effective vaccines against the respiratory syncytial viruses have been lacking since vaccine failures in the 1960s and 1970s. In this report, we describe a bovine respiratory syncytial virus (bRSV) challenge model in which both classical bRSV respiratory infection and vaccine-enhanced immune pathology were reproduced. The classical, formalin-inactivated (FI) bRSV vaccine that has been associated with vaccine failure was efficient in inducing high antibody titers and reducing viral loads but also primed calves for a far more serious enhanced respiratory disease after a bRSV challenge, thereby mimicking the enhanced clinical situation in FI human RSV (hRSV)-immunized and hRSV-infected infants in the 1960s. We show that immunization with FI-bRSV mainly primes a Th2-like inflammatory response that is characterized by a significant eosinophilic influx in the bronchial alveolar lung fluid and lung tissues and high levels of immunoglobulin E serum antibodies. The current model may be useful in the evaluation of new bRSV candidate vaccines for potency and safety
    Original languageEnglish
    Pages (from-to)12067-12073
    JournalJournal of Virology
    Volume77
    Issue number22
    DOIs
    Publication statusPublished - 2003

    Keywords

    • experimental reproduction
    • inactivated vaccine
    • rsv infection
    • calves
    • disease
    • antibodies
    • pneumonia
    • children
    • infants

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