Vaccination of pigs two weeks before infection significantly reduces transmission of foot-and-mouth disease virus

P.L. Eble, A. Bouma, M.G.M. de Bruin, F. van Hemert-Kluitenberg, J.T. van Oirschot, A. Dekker

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    57 Citations (Scopus)

    Abstract

    The objective of this study was to investigate whether and at what time interval could vaccination reduce transmission of foot-and-Mouth disease virus (FMDV) among pigs. Reduction of virus transmission by vaccination was determined experimentally. Transmission of FMDV was studied in three groups of ten pigs: one non-vaccinated group and two groups that were vaccinated 7 days (-7 dpi) and 14 days before inoculation (-14 dpi), respectively. Five randomly selected pigs from each group were inoculated with FMDV type O Taiwan, while the other five pigs left in the groups were exposed to the inoculated pigs by direct contact. Clinical signs were recorded, virus isolation and RT-PCR were carried out on oropharyngeal fluid (OPF), and the neutralizing antibody titres and the antibody response against non-structural (NS) proteins of FMDV were determined. No virus transmission was observed in the -14 dpi group, whereas virus transmission was observed in all contact pigs affecting both the non-vaccinated and the -7 dpi group. The reproduction ratio R in the -14 dpi vaccinated group was significantly lower than that of the non-vaccinated group. This study confirms the potential of vaccination as an important tool to reduce transmission of FMDV. (C) 2003 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)1372-1378
    JournalVaccine
    Volume22
    Issue number11-12
    DOIs
    Publication statusPublished - 2004

    Keywords

    • antibody-response
    • cattle
    • computation
    • reduction
    • emergency
    • epidemic
    • exposure
    • models

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