Vaccination of cattle against bovine viral diarrhoea

J.T. van Oirschot; C.J.M. Bruschke; P.A. van Rijn

doi:10.1016/S0378-1135(98)00268-5

Vaccination of cattle against bovine viral diarrhoea

J.T. van Oirschot, C.J.M. Bruschke, P.A. van Rijn

Virology & Molecular Biology

Research output: Contribution to journal › Article › Academic › peer-review

108 Citations (Scopus)

Abstract

This brief review describes types and quality (efficacy and safety) of bovine viral diarrhoea virus (BVDV) vaccines that are in the market or under development. Both conventional live and killed vaccines are available. The primary aim of vaccination is to prevent congenital infection, but the few vaccines tested are not highly efficacious in this respect, as shown in vaccination-challenge experiments. Vaccination to prevent severe postnatal infections may be indicated when virulent BVDV strains are prevalent. Live BVDV vaccines have given rise to safety problems. A complication for the development of BVDV vaccines is the wide antigenic diversity among wild-type BVDV. There is ample room for improvement of both the efficacy and safety of BVDV vaccines, and it may be expected that better vaccines, among which marker vaccines, will be launched in the future.

Original language	English
Pages (from-to)	169-183
Journal	Veterinary Microbiology
Volume	64
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-1135(98)00268-5
Publication status	Published - 1999

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title = "Vaccination of cattle against bovine viral diarrhoea",

abstract = "This brief review describes types and quality (efficacy and safety) of bovine viral diarrhoea virus (BVDV) vaccines that are in the market or under development. Both conventional live and killed vaccines are available. The primary aim of vaccination is to prevent congenital infection, but the few vaccines tested are not highly efficacious in this respect, as shown in vaccination-challenge experiments. Vaccination to prevent severe postnatal infections may be indicated when virulent BVDV strains are prevalent. Live BVDV vaccines have given rise to safety problems. A complication for the development of BVDV vaccines is the wide antigenic diversity among wild-type BVDV. There is ample room for improvement of both the efficacy and safety of BVDV vaccines, and it may be expected that better vaccines, among which marker vaccines, will be launched in the future.",

author = "{van Oirschot}, J.T. and C.J.M. Bruschke and {van Rijn}, P.A.",

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AB - This brief review describes types and quality (efficacy and safety) of bovine viral diarrhoea virus (BVDV) vaccines that are in the market or under development. Both conventional live and killed vaccines are available. The primary aim of vaccination is to prevent congenital infection, but the few vaccines tested are not highly efficacious in this respect, as shown in vaccination-challenge experiments. Vaccination to prevent severe postnatal infections may be indicated when virulent BVDV strains are prevalent. Live BVDV vaccines have given rise to safety problems. A complication for the development of BVDV vaccines is the wide antigenic diversity among wild-type BVDV. There is ample room for improvement of both the efficacy and safety of BVDV vaccines, and it may be expected that better vaccines, among which marker vaccines, will be launched in the future.

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JF - Veterinary Microbiology

SN - 0378-1135

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Vaccination of cattle against bovine viral diarrhoea

Abstract

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