Using new methodologies for a better understanding of the health impacts of petroleum substances

Hans Ketelslegers, Ivan Rusyn, Lenny Kamelia

Research output: Contribution to journalArticleAcademicpeer-review


Cat-App was initiated to minimize the need for testing in vertebrate animals under regulatory program. This is achieved by grouping petroleum substances (PS) to make the most optimal use of the toxicological information on PS by read-across of the available data within and between these groups. A framework will be developed for grouping based on chemical-biological properties combining multiple streams of information comprising PS production type/refining process, physical-chemical properties, chemical analytical profiles, existing (eco)toxicological data, and a comprehensive array of biological responses in a broad spectrum of in-vitro systems. Direct implementation of the Cat-App framework in the Concawe REACH strategy by applying the approach and submitting the data in the petroleum REACH dossiers will fill data gaps in the already-existing in-vivo toxicological data on PS, and help to develop a pragmatic and informed testing approach only as a last resort when read across to fill data gaps is not possible. This strategy will eventually address mandatory human health hazard end points under REACH while greatly reducing the use of vertebrate animals for toxicity testing without underestimating the potential hazards.
Original languageEnglish
Pages (from-to)15-15
JournalCONCAWE Review
Publication statusPublished - 2017


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