Abstract
This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological studies. It appears that results may differ when studying the same chemical in the same species in different target tissues. Another result of interest is the limited dose-response behavior of differential abundance patterns observed in studies where more than one dose level is tested. It is concluded that use of proteomics to study differences in modes of action of toxic compounds is an active area of research. The examples from use of proteomics to study sex-dependent differences also reveal that further studies are needed to provide reliable insight in modes of action, novel biomarkers or even novel therapies. To eventually reach this aim for this and other toxicological endpoints, it is essential to consider background variability, consequences of timing of toxicant administration, dose-response behavior, relevant species and target organ, species and organ variability and the presence of proteoforms.
| Original language | English |
|---|---|
| Pages (from-to) | 666-681 |
| Journal | Critical Reviews in Toxicology |
| Volume | 48 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 14 Sep 2018 |
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Keywords
- mode of action
- proteomics
- Sex related differences
- state-of-the-art
- toxicants
Cite this
}
Use of proteomics to detect sex-related differences in effects of toxicants : implications for using proteomics in toxicology. / Rietjens, Ivonne M.C.M.; Vervoort, Jacques; Maslowska-Górnicz, Anna; Van den Brink, Nico; Beekmann, Karsten.
In: Critical Reviews in Toxicology, Vol. 48, No. 8, 14.09.2018, p. 666-681.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Use of proteomics to detect sex-related differences in effects of toxicants
T2 - implications for using proteomics in toxicology
AU - Rietjens, Ivonne M.C.M.
AU - Vervoort, Jacques
AU - Maslowska-Górnicz, Anna
AU - Van den Brink, Nico
AU - Beekmann, Karsten
PY - 2018/9/14
Y1 - 2018/9/14
N2 - This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological studies. It appears that results may differ when studying the same chemical in the same species in different target tissues. Another result of interest is the limited dose-response behavior of differential abundance patterns observed in studies where more than one dose level is tested. It is concluded that use of proteomics to study differences in modes of action of toxic compounds is an active area of research. The examples from use of proteomics to study sex-dependent differences also reveal that further studies are needed to provide reliable insight in modes of action, novel biomarkers or even novel therapies. To eventually reach this aim for this and other toxicological endpoints, it is essential to consider background variability, consequences of timing of toxicant administration, dose-response behavior, relevant species and target organ, species and organ variability and the presence of proteoforms.
AB - This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological studies. It appears that results may differ when studying the same chemical in the same species in different target tissues. Another result of interest is the limited dose-response behavior of differential abundance patterns observed in studies where more than one dose level is tested. It is concluded that use of proteomics to study differences in modes of action of toxic compounds is an active area of research. The examples from use of proteomics to study sex-dependent differences also reveal that further studies are needed to provide reliable insight in modes of action, novel biomarkers or even novel therapies. To eventually reach this aim for this and other toxicological endpoints, it is essential to consider background variability, consequences of timing of toxicant administration, dose-response behavior, relevant species and target organ, species and organ variability and the presence of proteoforms.
KW - mode of action
KW - proteomics
KW - Sex related differences
KW - state-of-the-art
KW - toxicants
U2 - 10.1080/10408444.2018.1509941
DO - 10.1080/10408444.2018.1509941
M3 - Review article
VL - 48
SP - 666
EP - 681
JO - Critical Reviews in Toxicology
JF - Critical Reviews in Toxicology
SN - 1040-8444
IS - 8
ER -