Use of proteomics to detect sex-related differences in effects of toxicants: implications for using proteomics in toxicology

Ivonne M.C.M. Rietjens*, Jacques Vervoort, Anna Maslowska-Górnicz, Nico Van den Brink, Karsten Beekmann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

This review provides an overview of results obtained when using proteome analysis for detecting sex-based differences in response to toxicants. It reveals implications to be taken into account when considering the use of proteomics in toxicological studies. It appears that results may differ when studying the same chemical in the same species in different target tissues. Another result of interest is the limited dose-response behavior of differential abundance patterns observed in studies where more than one dose level is tested. It is concluded that use of proteomics to study differences in modes of action of toxic compounds is an active area of research. The examples from use of proteomics to study sex-dependent differences also reveal that further studies are needed to provide reliable insight in modes of action, novel biomarkers or even novel therapies. To eventually reach this aim for this and other toxicological endpoints, it is essential to consider background variability, consequences of timing of toxicant administration, dose-response behavior, relevant species and target organ, species and organ variability and the presence of proteoforms.

Original languageEnglish
Pages (from-to)666-681
JournalCritical Reviews in Toxicology
Volume48
Issue number8
DOIs
Publication statusPublished - 14 Sep 2018

Keywords

  • mode of action
  • proteomics
  • Sex related differences
  • state-of-the-art
  • toxicants

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