A P-glycoprotein gene probe from the sheep parasitic nematode Haemonchus contortus was developed and used to analyse restriction fragment length polymorphisms between susceptible isolates and isolates resistant to either benzimidazole; levamisole and benzimidazole; or benzimidazole, ivermectin and closantel. No polymorphism could be correlated with any of the different resistances. A P-glycoprotein gene probe was also isolated from the human nematode parasite Onchocerca volulus and an Onchocerca-specific PCR was developed.
Kwa, M. S. G., Okoli, M. N., Schulz-Key, H., Okongkwo, P. O., & Roos, M. H. (1998). Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus. International Journal for Parasitology, 28(8), 1235-1240. https://doi.org/10.1016/S0020-7519(98)00071-X