Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus

M.S.G. Kwa, M.N. Okoli, H. Schulz-Key, P.O. Okongkwo, M.H. Roos

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    34 Citations (Scopus)

    Abstract

    A P-glycoprotein gene probe from the sheep parasitic nematode Haemonchus contortus was developed and used to analyse restriction fragment length polymorphisms between susceptible isolates and isolates resistant to either benzimidazole; levamisole and benzimidazole; or benzimidazole, ivermectin and closantel. No polymorphism could be correlated with any of the different resistances. A P-glycoprotein gene probe was also isolated from the human nematode parasite Onchocerca volulus and an Onchocerca-specific PCR was developed.
    Original languageEnglish
    Pages (from-to)1235-1240
    JournalInternational Journal for Parasitology
    Volume28
    Issue number8
    DOIs
    Publication statusPublished - 1998

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