Use of omics analytical methods in the study of genetically modified maize varieties tested in 90 days feeding trials

Maria Corujo, Maria Pla*, Jeroen van Dijk, Marleen Voorhuijzen, Martijn Staats, Martijn Slot, Arjen Lommen, Eugenia Barros, Anna Nadal, Pere Puigdomènech, José Luís La Paz, Hilko van der Voet, Esther Kok

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Genetically modified (GM) maize and their non-modified counterparts were compared using MON810 varieties, the only GMO event cultivated in Europe. The differences in grain samples were analysed by omics profiles, including transcriptomics, proteomics and metabolomics. Other cultivated maize varieties were analysed as a reference for the variability that will exist between cultivated varieties. The observed differences between modified and non-modified maize varieties do not exceed typical differences between non-modified varieties. The use of these advanced analytical approaches to analyse novel plant materials as compared to the results from animal feeding trials with whole foods is assessed. No indications were observed for changes in the GM varieties that warrant further investigations. Furthermore, it was shown that such indications will be obtained if maize samples of inferior quality are analysed similarly. Omics data provide detailed analytical information of the plant material, which facilitates a risk assessment procedure of new (GM) plant varieties.

Original languageEnglish
Pages (from-to)359-371
JournalFood Chemistry
Volume292
Early online date26 May 2018
DOIs
Publication statusPublished - 15 Sep 2019

Keywords

  • GMO (genetically modified organism)
  • Metabolomics
  • One-class model
  • Proteomics
  • Risk assessment
  • Transcriptomics

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