TY - JOUR
T1 - Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients
AU - Post, Adrian
AU - Said, Yusof
AU - Gomes-Neto, Antonio W.
AU - van der Krogt, Jennifer
AU - de Blaauw, Pim
AU - Berger, Stefan P.
AU - Geleijnse, Johanna M.
AU - Borgonjen, Karin
AU - van den Berg, Else
AU - van Goor, Harry
AU - Rimbach, Gerald
AU - Kema, Ido P.
AU - Tsikas, Dimitrios
AU - Heiner-Fokkema, Rebecca
AU - Bakker, Stephan J.L.
PY - 2019/9/13
Y1 - 2019/9/13
N2 - Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is associated with low risk for development of late graft failure in renal transplant recipients (RTR). Urinary taurine excretion was measured in a longitudinal cohort of 678 stable RTR. Prospective associations were assessed using Cox regression analyses. Graft failure was defined as the start of dialysis or re-transplantation. In RTR (58% male, 53 ± 13 years old, estimated glomerular filtration rate (eGFR) 45 ± 19 mL/min/1.73 m2), urinary taurine excretion (533 (210-946) µmol/24 h) was significantly associated with serum free sulfhydryl groups (β = 0.126; P = 0.001). During median follow-up for 5.3 (4.5-6.0) years, 83 (12%) patients developed graft failure. In Cox regression analyses, urinary taurine excretion was inversely associated with graft failure (hazard ratio: 0.74 (0.67-0.82); P < 0.001). This association remained significant independent of potential confounders. High urinary taurine excretion is associated with low risk of late graft failure in RTR. Therefore, increasing taurine intake may potentially support graft survival in RTR. Further studies are warranted to determine the underlying mechanisms and the potential of taurine supplementation.
AB - Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is associated with low risk for development of late graft failure in renal transplant recipients (RTR). Urinary taurine excretion was measured in a longitudinal cohort of 678 stable RTR. Prospective associations were assessed using Cox regression analyses. Graft failure was defined as the start of dialysis or re-transplantation. In RTR (58% male, 53 ± 13 years old, estimated glomerular filtration rate (eGFR) 45 ± 19 mL/min/1.73 m2), urinary taurine excretion (533 (210-946) µmol/24 h) was significantly associated with serum free sulfhydryl groups (β = 0.126; P = 0.001). During median follow-up for 5.3 (4.5-6.0) years, 83 (12%) patients developed graft failure. In Cox regression analyses, urinary taurine excretion was inversely associated with graft failure (hazard ratio: 0.74 (0.67-0.82); P < 0.001). This association remained significant independent of potential confounders. High urinary taurine excretion is associated with low risk of late graft failure in RTR. Therefore, increasing taurine intake may potentially support graft survival in RTR. Further studies are warranted to determine the underlying mechanisms and the potential of taurine supplementation.
KW - graft survival
KW - renal transplant recipients
KW - taurine
KW - taurine excretion
U2 - 10.3390/nu11092212
DO - 10.3390/nu11092212
M3 - Article
C2 - 31540245
AN - SCOPUS:85072529719
SN - 2072-6643
VL - 11
JO - Nutrients
JF - Nutrients
IS - 9
M1 - 2212
ER -