Urinary and plasma magnesium and risk of ischemic heart disease

M.M. Joosten, R.T. Gansevoort, K.J. Mukamal, P. van der Harst, J.M. Geleijnse, E.J.M. Feskens, G. Navis, S.J.L. Bakker

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BACKGROUND: Previous studies on dietary magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual magnesium uptake. Urinary excretion of magnesium, an indicator of dietary magnesium uptake, might provide more consistent results. OBJECTIVE: The objective was to investigate whether urinary magnesium excretion and plasma magnesium are associated with IHD risk. DESIGN: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study-a prospective population-based cohort study. Urinary magnesium excretion was measured in 2 baseline 24-h urine collections. RESULTS: Mean ± SD urinary magnesium excretion was 4.24 ± 1.65 mmol/24 h for men and 3.54 ± 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary magnesium excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men:
Original languageEnglish
Pages (from-to)1299-1306
JournalAmerican Journal of Clinical Nutrition
Issue number6
Publication statusPublished - 2013


  • dietary magnesium
  • endothelial dysfunction
  • systemic inflammation
  • atherosclerosis risk
  • metabolic syndrome
  • coronary-arteries
  • national sample
  • serum magnesium
  • blood-pressure
  • sudden-death


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