Abstract
BACKGROUND: Previous studies on dietary magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual magnesium uptake. Urinary excretion of magnesium, an indicator of dietary magnesium uptake, might provide more consistent results.
OBJECTIVE: The objective was to investigate whether urinary magnesium excretion and plasma magnesium are associated with IHD risk.
DESIGN: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study-a prospective population-based cohort study. Urinary magnesium excretion was measured in 2 baseline 24-h urine collections.
RESULTS: Mean ± SD urinary magnesium excretion was 4.24 ± 1.65 mmol/24 h for men and 3.54 ± 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary magnesium excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men:
| Original language | English |
|---|---|
| Pages (from-to) | 1299-1306 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 97 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2013 |
Keywords
- dietary magnesium
- endothelial dysfunction
- systemic inflammation
- atherosclerosis risk
- metabolic syndrome
- coronary-arteries
- national sample
- serum magnesium
- blood-pressure
- sudden-death