Uptake and elimination of 1,2,4-trichlorobenzene in the guppy (Poecilia reticulata) at sublethal and lethal aqueous concentrations.

J.M.C. van Eck, A.A. Koelmans, J.W. Deneer

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

The kinetics of 1,2,4-trichlorobenzene in guppies (Poecilia reticulata) have been studied in an accumulation and elimination experiment. At a sublethal exposure, uptake and elimination rate constants of 1,2,4-trichlorobenzene were determined, employing a first-order one-compartment model. The constants were found to be 492 ± 234 Lkg−1 d−1 (uptake), and 0.49 ± 0.22 d−1 (elimination) on the basis of wet weight. Exposing guppies to a time-varying lethal concentration of 1,2,4-trichlorobenzene for three weeks, it was found that the model gives a satisfactorily prediction of fish residues at lethal exposures on the basis of toxicokinetic parameters determined at sublethal exposures. During the first days residues were over-estimated. This may be due to a period of immobility before fish are dying. Kinetic parameters may be lower during immobility.
Original languageEnglish
Pages (from-to)2259-2270
JournalChemosphere
Volume34
DOIs
Publication statusPublished - 1997

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