Update of the risk assessment of inorganic arsenic in food

Dieter Schrenk; Margherita Bignami; Laurent Bodin; James Kevin Chipman; Jesus del Mazo; Bettina Grasl‐Kraupp; Christer Hogstrand; L.A.P. Hoogenboom; Jean Charles Leblanc; Carlo Stefano Nebbia; Elsa Nielsen; Evangelia Ntzani; Annette Petersen; Salomon Sand; Christiane Vleminckx; Heather Wallace; Lars Barregård; Diane Benford; Karin Broberg; Eugenia Dogliotti; Tony Fletcher; Lars Rylander; José Cortiñas Abrahantes; José Ángel Gómez Ruiz; Hans Steinkellner; Tuuli Tauriainen; Tanja Schwerdtle

doi:10.2903/j.efsa.2024.8488

Update of the risk assessment of inorganic arsenic in food

Dieter Schrenk
, Margherita Bignami
, Laurent Bodin
, James Kevin Chipman
, Jesus del Mazo
, Bettina Grasl‐Kraupp
, Christer Hogstrand
, L.A.P. Hoogenboom
, Jean Charles Leblanc
, Carlo Stefano Nebbia
, Elsa Nielsen
, Evangelia Ntzani
, Annette Petersen
, Salomon Sand
, Christiane Vleminckx
, Heather Wallace
, Lars Barregård
, Diane Benford
, Karin Broberg
, Eugenia Dogliotti

Tony Fletcher, Lars Rylander, José Cortiñas Abrahantes, José Ángel Gómez Ruiz, Hans Steinkellner, Tuuli Tauriainen, Tanja Schwerdtle

Research output: Contribution to journal › Article › Academic › peer-review

130 Citations (Scopus)

Abstract

The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.

Original language	English
Article number	e8488
Number of pages	191
Journal	EFSA Journal
Volume	22
Issue number	1
DOIs	https://doi.org/10.2903/j.efsa.2024.8488
Publication status	Published - 18 Jan 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.2903/j.efsa.2024.8488Licence: CC BY-ND

https://edepot.wur.nl/685809Licence: CC BY-ND

Annex F - BMD summary table
Schrenk, D. (Creator), Bignami, M. (Creator), Bodin, L. (Creator), Chipman, J. K. (Creator), del Mazo, J. (Creator), Grasl‐Kraupp, B. (Creator), Hogstrand, C. (Creator), Hoogenboom, L. A. P. (Creator), Leblanc, J. C. (Creator), Nebbia, C. S. (Creator), Nielsen, E. (Creator), Ntzani, E. (Creator), Petersen, A. (Creator), Sand, S. (Creator), Vleminckx, C. (Creator), Wallace, H. (Creator), Barregård, L. (Creator), Benford, D. (Creator), Broberg, K. (Creator), Dogliotti, E. (Creator), Fletcher, T. (Creator), Rylander, L. (Creator), Abrahantes, J. C. (Creator), Gómez Ruiz, J. Á. (Creator), Steinkellner, H. (Creator), Tauriainen, T. (Creator) & Schwerdtle, T. (Creator), Technische Universität Kaiserslautern, 18 Jan 2024
DOI: 10.5281/zenodo.10460958
Dataset
Annex D2 - Exposure estimates and transformations (u-tiAs studies)
Schrenk, D. (Creator), Bignami, M. (Creator), Bodin, L. (Creator), Chipman, J. K. (Creator), del Mazo, J. (Creator), Grasl‐Kraupp, B. (Creator), Hogstrand, C. (Creator), Hoogenboom, L. A. P. (Creator), Leblanc, J. C. (Creator), Nebbia, C. S. (Creator), Nielsen, E. (Creator), Ntzani, E. (Creator), Petersen, A. (Creator), Sand, S. (Creator), Vleminckx, C. (Creator), Wallace, H. (Creator), Barregård, L. (Creator), Benford, D. (Creator), Broberg, K. (Creator), Dogliotti, E. (Creator), Fletcher, T. (Creator), Rylander, L. (Creator), Abrahantes, J. C. (Creator), Gómez Ruiz, J. Á. (Creator), Steinkellner, H. (Creator), Tauriainen, T. (Creator) & Schwerdtle, T. (Creator), Technische Universität Kaiserslautern, 18 Jan 2024
DOI: 10.5281/zenodo.10460951
Dataset
Annex D1 - Exposure estimates and transformations (w-tiAs studies)
Schrenk, D. (Creator), Bignami, M. (Creator), Bodin, L. (Creator), Chipman, J. K. (Creator), del Mazo, J. (Creator), Grasl‐Kraupp, B. (Creator), Hogstrand, C. (Creator), Hoogenboom, L. A. P. (Creator), Leblanc, J. C. (Creator), Nebbia, C. S. (Creator), Nielsen, E. (Creator), Ntzani, E. (Creator), Petersen, A. (Creator), Sand, S. (Creator), Vleminckx, C. (Creator), Wallace, H. (Creator), Barregård, L. (Creator), Benford, D. (Creator), Broberg, K. (Creator), Dogliotti, E. (Creator), Fletcher, T. (Creator), Rylander, L. (Creator), Abrahantes, J. C. (Creator), Gómez Ruiz, J. Á. (Creator), Steinkellner, H. (Creator), Tauriainen, T. (Creator) & Schwerdtle, T. (Creator), Technische Universität Kaiserslautern, 18 Jan 2024
DOI: 10.5281/zenodo.10459766
Dataset

Deelname en ondersteuning van EFSA en CODEX panels en werkgroepen (WOT-02-001-057)
Hoogenboom, R. (Project Leader)
1/01/13 → 31/12/26
Project: LVVN project

Cite this

Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. A. P., Leblanc, J. C., Nebbia, C. S., Nielsen, E., Ntzani, E., Petersen, A., Sand, S., Vleminckx, C., Wallace, H., Barregård, L., Benford, D., Broberg, K., ... Schwerdtle, T. (2024). Update of the risk assessment of inorganic arsenic in food. EFSA Journal, 22(1), Article e8488. https://doi.org/10.2903/j.efsa.2024.8488

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abstract = "The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5\% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.",

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Schrenk, D, Bignami, M, Bodin, L, Chipman, JK, del Mazo, J, Grasl‐Kraupp, B, Hogstrand, C, Hoogenboom, LAP, Leblanc, JC, Nebbia, CS, Nielsen, E, Ntzani, E, Petersen, A, Sand, S, Vleminckx, C, Wallace, H, Barregård, L, Benford, D, Broberg, K, Dogliotti, E, Fletcher, T, Rylander, L, Abrahantes, JC, Gómez Ruiz, JÁ, Steinkellner, H, Tauriainen, T & Schwerdtle, T 2024, 'Update of the risk assessment of inorganic arsenic in food', EFSA Journal, vol. 22, no. 1, e8488. https://doi.org/10.2903/j.efsa.2024.8488

TY - JOUR

T1 - Update of the risk assessment of inorganic arsenic in food

AU - Schrenk, Dieter

AU - Bignami, Margherita

AU - Bodin, Laurent

AU - Chipman, James Kevin

AU - del Mazo, Jesus

AU - Grasl‐Kraupp, Bettina

AU - Hogstrand, Christer

AU - Hoogenboom, L.A.P.

AU - Leblanc, Jean Charles

AU - Nebbia, Carlo Stefano

AU - Nielsen, Elsa

AU - Ntzani, Evangelia

AU - Petersen, Annette

AU - Sand, Salomon

AU - Vleminckx, Christiane

AU - Wallace, Heather

AU - Barregård, Lars

AU - Benford, Diane

AU - Broberg, Karin

AU - Dogliotti, Eugenia

AU - Fletcher, Tony

AU - Rylander, Lars

AU - Abrahantes, José Cortiñas

AU - Gómez Ruiz, José Ángel

AU - Steinkellner, Hans

AU - Tauriainen, Tuuli

AU - Schwerdtle, Tanja

PY - 2024/1/18

Y1 - 2024/1/18

N2 - The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.

AB - The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.

U2 - 10.2903/j.efsa.2024.8488

DO - 10.2903/j.efsa.2024.8488

M3 - Article

SN - 1831-4732

VL - 22

JO - EFSA Journal

JF - EFSA Journal

IS - 1

M1 - e8488

ER -

Update of the risk assessment of inorganic arsenic in food

Abstract

UN SDGs

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Datasets

Annex F - BMD summary table

Annex D2 - Exposure estimates and transformations (u-tiAs studies)

Annex D1 - Exposure estimates and transformations (w-tiAs studies)

Projects

Deelname en ondersteuning van EFSA en CODEX panels en werkgroepen (WOT-02-001-057)

Cite this