Unique features of glycolysis in Archaea

C.H. Verhees, S.W.M. Kengen, J.E. Tuininga, G.J. Schut, M.W.W. Adams, W.M. de Vos, J. van der Oost

Research output: Contribution to journalArticleAcademicpeer-review

181 Citations (Scopus)


An early divergence in evolution has resulted in two prokaryotic domains, the Bacteria and the Archaea. Whereas the central metabolic routes of bacteria and eukaryotes are generally well-conserved, variant pathways have developed in Archaea involving several novel enzymes with a distinct control. A spectacular example of convergent evolution concerns the glucose-degrading pathways of saccharolytic archaea. The identification, characterization and comparison of the glycolytic enzymes of a variety of phylogenetic lineages have revealed a mosaic of canonical and novel enzymes in the archaeal variants of the Embden-Meyerhof and the Entner-Doudoroff pathways. By means of integrating results from biochemical and genetic studies with recently obtained comparative and functional genomics data, the structure and function of the archaeal glycolytic routes, the participating enzymes and their regulation are re-evaluated.
Original languageEnglish
Pages (from-to)231-246
JournalBiochemical Journal
Publication statusPublished - 2003


  • archaebacterium sulfolobus-solfataricus
  • adp-dependent phosphofructokinase
  • extracellular alpha-amylase
  • entner-doudoroff-pathway
  • embden-meyerhof pathway
  • dna microarray analysis
  • sea hydrothermal vent
  • coenzyme-a synthetase
  • class-i aldolase
  • hypertherm


Dive into the research topics of 'Unique features of glycolysis in Archaea'. Together they form a unique fingerprint.

Cite this