Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial

M.J. Grubben, G.H. Boers, H.J. Blom, R. Broekhuizen, R. de Jong, L. van Rijt, M.B. Katan

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Abstract

Background: An elevated plasma homocysteine concentration is a putative risk factor for cardiovascular disease. Observational studies have reported an association between coffee consumption and plasma homocysteine concentrations. Objective: We studied the effect of coffee consumption on plasma homocysteine in a crossover trial. We used unfiltered coffee so as to include the possible effects of coffee diterpenes, which are removed by filtering. Design: Sixty-four healthy volunteers (31 men and 33 women) with a mean (±SD) age of 43 ± 11 y were randomly assigned to 2 groups. One group (n = 30) drank 1 L unfiltered cafetière (French press) coffee daily for 2 wk. Such coffee is rich in the cholesterol-raising diterpenes kahweol and cafestol. The other group (n = 34) received water, milk, broth, tea, and chocolate drinks instead of coffee. After a washout period of 8 wk, both groups received the alternate intervention for another 2 wk. Results: Consumption of 1 L unfiltered coffee/d for 2 wk significantly raised fasting plasma homocysteine concentrations by 10°from 12.8 to 14.0 mmol/L. Conclusions: Unfiltered coffee increases plasma homocysteine concentrations in volunteers with normal initial concentrations. It is unclear whether the effect is caused by the cholesterol-raising diterpenes present exclusively in unfiltered coffee or by factors that are also present in filtered coffee.
Original languageEnglish
Pages (from-to)480-484
JournalAmerican Journal of Clinical Nutrition
Volume71
DOIs
Publication statusPublished - 2000

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Coffee
Homocysteine
Healthy Volunteers
Diterpenes
Cholesterol
Tea
Cross-Over Studies
Observational Studies
Fasting
Milk
Cardiovascular Diseases

Cite this

Grubben, M. J., Boers, G. H., Blom, H. J., Broekhuizen, R., de Jong, R., van Rijt, L., & Katan, M. B. (2000). Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. American Journal of Clinical Nutrition, 71, 480-484. https://doi.org/10.1093/ajcn/71.2.480
Grubben, M.J. ; Boers, G.H. ; Blom, H.J. ; Broekhuizen, R. ; de Jong, R. ; van Rijt, L. ; Katan, M.B. / Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. In: American Journal of Clinical Nutrition. 2000 ; Vol. 71. pp. 480-484.
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abstract = "Background: An elevated plasma homocysteine concentration is a putative risk factor for cardiovascular disease. Observational studies have reported an association between coffee consumption and plasma homocysteine concentrations. Objective: We studied the effect of coffee consumption on plasma homocysteine in a crossover trial. We used unfiltered coffee so as to include the possible effects of coffee diterpenes, which are removed by filtering. Design: Sixty-four healthy volunteers (31 men and 33 women) with a mean (±SD) age of 43 ± 11 y were randomly assigned to 2 groups. One group (n = 30) drank 1 L unfiltered cafeti{\`e}re (French press) coffee daily for 2 wk. Such coffee is rich in the cholesterol-raising diterpenes kahweol and cafestol. The other group (n = 34) received water, milk, broth, tea, and chocolate drinks instead of coffee. After a washout period of 8 wk, both groups received the alternate intervention for another 2 wk. Results: Consumption of 1 L unfiltered coffee/d for 2 wk significantly raised fasting plasma homocysteine concentrations by 10°from 12.8 to 14.0 mmol/L. Conclusions: Unfiltered coffee increases plasma homocysteine concentrations in volunteers with normal initial concentrations. It is unclear whether the effect is caused by the cholesterol-raising diterpenes present exclusively in unfiltered coffee or by factors that are also present in filtered coffee.",
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Grubben, MJ, Boers, GH, Blom, HJ, Broekhuizen, R, de Jong, R, van Rijt, L & Katan, MB 2000, 'Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial', American Journal of Clinical Nutrition, vol. 71, pp. 480-484. https://doi.org/10.1093/ajcn/71.2.480

Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. / Grubben, M.J.; Boers, G.H.; Blom, H.J.; Broekhuizen, R.; de Jong, R.; van Rijt, L.; Katan, M.B.

In: American Journal of Clinical Nutrition, Vol. 71, 2000, p. 480-484.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Grubben, M.J.

AU - Boers, G.H.

AU - Blom, H.J.

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N2 - Background: An elevated plasma homocysteine concentration is a putative risk factor for cardiovascular disease. Observational studies have reported an association between coffee consumption and plasma homocysteine concentrations. Objective: We studied the effect of coffee consumption on plasma homocysteine in a crossover trial. We used unfiltered coffee so as to include the possible effects of coffee diterpenes, which are removed by filtering. Design: Sixty-four healthy volunteers (31 men and 33 women) with a mean (±SD) age of 43 ± 11 y were randomly assigned to 2 groups. One group (n = 30) drank 1 L unfiltered cafetière (French press) coffee daily for 2 wk. Such coffee is rich in the cholesterol-raising diterpenes kahweol and cafestol. The other group (n = 34) received water, milk, broth, tea, and chocolate drinks instead of coffee. After a washout period of 8 wk, both groups received the alternate intervention for another 2 wk. Results: Consumption of 1 L unfiltered coffee/d for 2 wk significantly raised fasting plasma homocysteine concentrations by 10°from 12.8 to 14.0 mmol/L. Conclusions: Unfiltered coffee increases plasma homocysteine concentrations in volunteers with normal initial concentrations. It is unclear whether the effect is caused by the cholesterol-raising diterpenes present exclusively in unfiltered coffee or by factors that are also present in filtered coffee.

AB - Background: An elevated plasma homocysteine concentration is a putative risk factor for cardiovascular disease. Observational studies have reported an association between coffee consumption and plasma homocysteine concentrations. Objective: We studied the effect of coffee consumption on plasma homocysteine in a crossover trial. We used unfiltered coffee so as to include the possible effects of coffee diterpenes, which are removed by filtering. Design: Sixty-four healthy volunteers (31 men and 33 women) with a mean (±SD) age of 43 ± 11 y were randomly assigned to 2 groups. One group (n = 30) drank 1 L unfiltered cafetière (French press) coffee daily for 2 wk. Such coffee is rich in the cholesterol-raising diterpenes kahweol and cafestol. The other group (n = 34) received water, milk, broth, tea, and chocolate drinks instead of coffee. After a washout period of 8 wk, both groups received the alternate intervention for another 2 wk. Results: Consumption of 1 L unfiltered coffee/d for 2 wk significantly raised fasting plasma homocysteine concentrations by 10°from 12.8 to 14.0 mmol/L. Conclusions: Unfiltered coffee increases plasma homocysteine concentrations in volunteers with normal initial concentrations. It is unclear whether the effect is caused by the cholesterol-raising diterpenes present exclusively in unfiltered coffee or by factors that are also present in filtered coffee.

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