TSE pathogenesis in cattle and sheep

L.J.M. van Keulen, A. Bossers, F.G. van Zijderveld

    Research output: Contribution to journalArticleAcademicpeer-review

    87 Citations (Scopus)


    Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts. In this review, we summarize the most recent insights into the pathogenesis of BSE and scrapie starting from the initial uptake of TSE agents and crossing of the gut epithelium. Following replication in the gut-associated lymphoid tissues (GALT), TSE agents spread to the enteric nervous system (ENS) of the gut. Infection is then carried through the efferent fibers of the post-ganglionic neurons of the parasympathetic and sympathetic nervous system to the pre-ganglionic neurons in the medulla oblongata of the brain and the thoracic segments of the spinal cord. The differences between the pathogenesis of BSE in cattle and scrapie in sheep are discussed as well as the possible existence of additional pathogenetic routes.
    Original languageEnglish
    Article number24
    Number of pages12
    JournalVeterinary Research
    Issue number4
    Publication statusPublished - 2008


    • bovine spongiform encephalopathy
    • follicular dendritic cells
    • scrapie-infected sheep
    • gut epithelial monolayers
    • disease-specific prp
    • natural scrapie
    • prion protein
    • immunohistochemical detection
    • lateral transmission
    • lymphoid-tissues


    Dive into the research topics of 'TSE pathogenesis in cattle and sheep'. Together they form a unique fingerprint.

    Cite this