TY - JOUR
T1 - Tropane and ergot alkaloids in grain-based products for infants and young children in the Netherlands in 2011–2014
AU - Mulder, P.P.J.
AU - Pereboom-de Fauw, D.P.K.H.
AU - Hoogenboom, R.L.A.P.
AU - de Stoppelaar, Joyce
AU - de Nijs, Monique
PY - 2015
Y1 - 2015
N2 - An LC-MS/MS multi-method was developed to simultaneously quantify ergot alkaloids (EAs) and tropane alkaloids (TAs) in 113 cereal-based food for infants and young children. To assess yearly variation, samples were collected in 2011, 2012 and 2014. EAs were detected in 54% and TAs in 22% of the samples. Mean EA levels in the three sampling years were 10.6, 6.2 and 8.6 µg kg−1, respectively (maximum: 115.4 µg kg−1), indicating that exposure to EAs would not have exceeded the health-based guidance values set by EFSA in 2012. Mean TA levels were 3.9, 2.4 and 0.4 µg kg−1, respectively (maximum: 80.8 µg kg−1). The acute reference dose for TAs, derived by EFSA in 2013, would have been exceeded by young children when consuming some of the products sampled in 2011–2012. TA levels had decreased drastically in 2014, possibly due to measures taken by producers as response to the EFSA Opinion.
AB - An LC-MS/MS multi-method was developed to simultaneously quantify ergot alkaloids (EAs) and tropane alkaloids (TAs) in 113 cereal-based food for infants and young children. To assess yearly variation, samples were collected in 2011, 2012 and 2014. EAs were detected in 54% and TAs in 22% of the samples. Mean EA levels in the three sampling years were 10.6, 6.2 and 8.6 µg kg−1, respectively (maximum: 115.4 µg kg−1), indicating that exposure to EAs would not have exceeded the health-based guidance values set by EFSA in 2012. Mean TA levels were 3.9, 2.4 and 0.4 µg kg−1, respectively (maximum: 80.8 µg kg−1). The acute reference dose for TAs, derived by EFSA in 2013, would have been exceeded by young children when consuming some of the products sampled in 2011–2012. TA levels had decreased drastically in 2014, possibly due to measures taken by producers as response to the EFSA Opinion.
KW - cereal-based food
KW - ergot alkaloids
KW - LC-MS/MS
KW - multi-method
KW - tropane alkaloids
KW - young children
U2 - 10.1080/19393210.2015.1089947
DO - 10.1080/19393210.2015.1089947
M3 - Article
AN - SCOPUS:84946532287
SP - 284
EP - 290
JO - Food Additives & Contaminants Part B-Surveillance
JF - Food Additives & Contaminants Part B-Surveillance
SN - 1939-3210
M1 - 4
ER -