Triggered Templated Assembly of Protein Polymersomes

F. Li; F.A. de Wolf; A.T.M. Marcelis; E.J.R. Sudhölter; M.A.C. Stuart; F.A.M. Leermakers

doi:10.1002/anie.201004003

Triggered Templated Assembly of Protein Polymersomes

F. Li, F.A. de Wolf, A.T.M. Marcelis, E.J.R. Sudhölter, M.A.C. Stuart, F.A.M. Leermakers

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

Trigger the block: Stable biocompatible protein polymersomes can be generated by a triggered templated self-assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CSXSXC into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.

Original language	English
Pages (from-to)	9947-9950
Journal	Angewandte Chemie-International Edition
Volume	49
Issue number	51
DOIs	https://doi.org/10.1002/anie.201004003
Publication status	Published - 2010

Keywords

aqueous-solution
vesicles
copolymers

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10.1002/anie.201004003

Cite this

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abstract = "Trigger the block: Stable biocompatible protein polymersomes can be generated by a triggered templated self-assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CSXSXC into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.",

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AU - Li, F.

AU - de Wolf, F.A.

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AU - Sudhölter, E.J.R.

AU - Stuart, M.A.C.

AU - Leermakers, F.A.M.

PY - 2010

Y1 - 2010

N2 - Trigger the block: Stable biocompatible protein polymersomes can be generated by a triggered templated self-assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CSXSXC into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.

AB - Trigger the block: Stable biocompatible protein polymersomes can be generated by a triggered templated self-assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CSXSXC into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.

KW - aqueous-solution

KW - vesicles

KW - copolymers

U2 - 10.1002/anie.201004003

DO - 10.1002/anie.201004003

M3 - Article

SN - 1433-7851

VL - 49

SP - 9947

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JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

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ER -

Triggered Templated Assembly of Protein Polymersomes

Abstract

Keywords

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