Triggered Templated Assembly of Protein Polymersomes

F. Li, F.A. de Wolf, A.T.M. Marcelis, E.J.R. Sudhölter, M.A.C. Stuart, F.A.M. Leermakers

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)


Trigger the block: Stable biocompatible protein polymersomes can be generated by a triggered templated self-assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CSXSXC into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.
Original languageEnglish
Pages (from-to)9947-9950
JournalAngewandte Chemie-International Edition
Issue number51
Publication statusPublished - 2010


  • aqueous-solution
  • vesicles
  • copolymers


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