Abstract
We describe a previously undetected domain – TRASH – containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.
Original language | English |
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Pages (from-to) | 170-173 |
Journal | Trends in Biochemical Sciences |
Volume | 28 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- copper chaperones
- disease proteins
- metallochaperone
- database
- atpases