TRASH, a novel metal binding domain predicted to be involved in heavy metal sensing, trafficking and resistance

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Abstract

We describe a previously undetected domain – TRASH – containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.
Original languageEnglish
Pages (from-to)170-173
JournalTrends in Biochemical Sciences
Volume28
Issue number4
DOIs
Publication statusPublished - 2003

Keywords

  • copper chaperones
  • disease proteins
  • metallochaperone
  • database
  • atpases

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