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Abstract
Potential vertical transmission of wild-type bluetongue virus serotype 8 (BTV-8) in cattle was explored in this experiment. We demonstrated transplacental transmission of wild-type BTV-8 in one calf and oral infection with BTV-8 in another calf. Following the experimental BTV-8 infection of seven out of fifteen multi-parous cows eight months in gestation, each newborn calf was tested prior to colostrum intake for transplacental transmission of BTV by RRT-PCR. If transplacental transmission was not established the calves were fed colostrum from infected dams or colostrum from non-infected dams spiked with BTV-8 containing blood. One calf from an infected dam was born RRT-PCR positive and BTV-specific antibody (Abs) negative, BTV was isolated from its blood. It was born with clinical signs resembling bluetongue and lived for two days. Its post-mortem tissue suspensions were RRT-PCR positive. Of the seven calves fed colostrum from infected dams, none became infected. Of the six calves fed colostrum from non-infected dams spiked with infected blood, one calf became PCR-positive at day 8 post-partum (dpp), seroconverted 27 days later, and remained RRT-PCR and Abs positive for the duration of the experiment (i.e., 70 dpp). This work demonstrates that transplacental transmission in late gestation and oral infection of the neonate with wild-type BTV-8 is possible in cattle under experimental conditions
Original language | English |
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Pages (from-to) | 235-243 |
Journal | Veterinary Microbiology |
Volume | 138 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- possible overwintering mechanism
- maedi-visna-virus
- northern europe
- clinical signs
- pregnant ewes
- sheep
- calves
- culicoides
- vector
- pathogenesis
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Virale zoönosen en vectorgebonden ziekten (WOT-01-002-041, WOT-01-003-015)
Holwerda, M. (Project Leader)
1/01/08 → 31/12/25
Project: LVVN project