Transmission through air as a possible route of exposure for MRSA

Marian E.H. Bos, Koen M. Verstappen, Brigitte A.G.L. Van Cleef, Wietske Dohmen, Alejandro Dorado-García, Haitske Graveland, Birgitta Duim, Jaap A. Wagenaar, Jan A.J.W. Kluytmans, Dick J.J. Heederik

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Abstract

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is highly prevalent in pigs and veal calves. The environment and air in pig and veal calf barns is often contaminated with LA-MRSA, and can act as a transmission source for humans. This study explores exposure-response relationships between sequence type 398 (ST398) MRSA air exposure level and nasal ST398 MRSA carriage in people working and/or living on farms. Samples and data were used from three longitudinal field studies in pig and veal calf farm populations. Samples consisted of nasal swabs from the human participants and electrostatic dust fall collectors capturing airborne settled dust in barns. In both multivariate and mutually adjusted analyses, a strong association was found between nasal ST398 MRSA carriage in people working in the barns for >20 h per week and MRSA air levels. In people working in the barns <20 h per week there was a strong association between nasal carriage and number of working hours. Exposure to ST398 MRSA in barn air seems to be an important determinant for nasal carriage, especially in the highly exposed group of farmers, next to duration of contact with animals. Intervention measures should therefore probably also target reduction of ST398 MRSA air levels.

Original languageEnglish
Pages (from-to)263-269
JournalJournal of Exposure Science and Environmental Epidemiology
Volume26
Issue number3
DOIs
Publication statusPublished - 2016

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Farms
Air
Nose
Methicillin
Swine
Association reactions
Dust collectors
Livestock
Dust
Electrostatics
Animals
Static Electricity
Longitudinal Studies
Population

Keywords

  • air
  • exposure
  • livestock
  • MRSA
  • transmission

Cite this

Bos, M. E. H., Verstappen, K. M., Van Cleef, B. A. G. L., Dohmen, W., Dorado-García, A., Graveland, H., ... Heederik, D. J. J. (2016). Transmission through air as a possible route of exposure for MRSA. Journal of Exposure Science and Environmental Epidemiology, 26(3), 263-269. https://doi.org/10.1038/jes.2014.85
Bos, Marian E.H. ; Verstappen, Koen M. ; Van Cleef, Brigitte A.G.L. ; Dohmen, Wietske ; Dorado-García, Alejandro ; Graveland, Haitske ; Duim, Birgitta ; Wagenaar, Jaap A. ; Kluytmans, Jan A.J.W. ; Heederik, Dick J.J. / Transmission through air as a possible route of exposure for MRSA. In: Journal of Exposure Science and Environmental Epidemiology. 2016 ; Vol. 26, No. 3. pp. 263-269.
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abstract = "Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is highly prevalent in pigs and veal calves. The environment and air in pig and veal calf barns is often contaminated with LA-MRSA, and can act as a transmission source for humans. This study explores exposure-response relationships between sequence type 398 (ST398) MRSA air exposure level and nasal ST398 MRSA carriage in people working and/or living on farms. Samples and data were used from three longitudinal field studies in pig and veal calf farm populations. Samples consisted of nasal swabs from the human participants and electrostatic dust fall collectors capturing airborne settled dust in barns. In both multivariate and mutually adjusted analyses, a strong association was found between nasal ST398 MRSA carriage in people working in the barns for >20 h per week and MRSA air levels. In people working in the barns <20 h per week there was a strong association between nasal carriage and number of working hours. Exposure to ST398 MRSA in barn air seems to be an important determinant for nasal carriage, especially in the highly exposed group of farmers, next to duration of contact with animals. Intervention measures should therefore probably also target reduction of ST398 MRSA air levels.",
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Bos, MEH, Verstappen, KM, Van Cleef, BAGL, Dohmen, W, Dorado-García, A, Graveland, H, Duim, B, Wagenaar, JA, Kluytmans, JAJW & Heederik, DJJ 2016, 'Transmission through air as a possible route of exposure for MRSA' Journal of Exposure Science and Environmental Epidemiology, vol. 26, no. 3, pp. 263-269. https://doi.org/10.1038/jes.2014.85

Transmission through air as a possible route of exposure for MRSA. / Bos, Marian E.H.; Verstappen, Koen M.; Van Cleef, Brigitte A.G.L.; Dohmen, Wietske; Dorado-García, Alejandro; Graveland, Haitske; Duim, Birgitta; Wagenaar, Jaap A.; Kluytmans, Jan A.J.W.; Heederik, Dick J.J.

In: Journal of Exposure Science and Environmental Epidemiology, Vol. 26, No. 3, 2016, p. 263-269.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Transmission through air as a possible route of exposure for MRSA

AU - Bos, Marian E.H.

AU - Verstappen, Koen M.

AU - Van Cleef, Brigitte A.G.L.

AU - Dohmen, Wietske

AU - Dorado-García, Alejandro

AU - Graveland, Haitske

AU - Duim, Birgitta

AU - Wagenaar, Jaap A.

AU - Kluytmans, Jan A.J.W.

AU - Heederik, Dick J.J.

PY - 2016

Y1 - 2016

N2 - Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is highly prevalent in pigs and veal calves. The environment and air in pig and veal calf barns is often contaminated with LA-MRSA, and can act as a transmission source for humans. This study explores exposure-response relationships between sequence type 398 (ST398) MRSA air exposure level and nasal ST398 MRSA carriage in people working and/or living on farms. Samples and data were used from three longitudinal field studies in pig and veal calf farm populations. Samples consisted of nasal swabs from the human participants and electrostatic dust fall collectors capturing airborne settled dust in barns. In both multivariate and mutually adjusted analyses, a strong association was found between nasal ST398 MRSA carriage in people working in the barns for >20 h per week and MRSA air levels. In people working in the barns <20 h per week there was a strong association between nasal carriage and number of working hours. Exposure to ST398 MRSA in barn air seems to be an important determinant for nasal carriage, especially in the highly exposed group of farmers, next to duration of contact with animals. Intervention measures should therefore probably also target reduction of ST398 MRSA air levels.

AB - Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is highly prevalent in pigs and veal calves. The environment and air in pig and veal calf barns is often contaminated with LA-MRSA, and can act as a transmission source for humans. This study explores exposure-response relationships between sequence type 398 (ST398) MRSA air exposure level and nasal ST398 MRSA carriage in people working and/or living on farms. Samples and data were used from three longitudinal field studies in pig and veal calf farm populations. Samples consisted of nasal swabs from the human participants and electrostatic dust fall collectors capturing airborne settled dust in barns. In both multivariate and mutually adjusted analyses, a strong association was found between nasal ST398 MRSA carriage in people working in the barns for >20 h per week and MRSA air levels. In people working in the barns <20 h per week there was a strong association between nasal carriage and number of working hours. Exposure to ST398 MRSA in barn air seems to be an important determinant for nasal carriage, especially in the highly exposed group of farmers, next to duration of contact with animals. Intervention measures should therefore probably also target reduction of ST398 MRSA air levels.

KW - air

KW - exposure

KW - livestock

KW - MRSA

KW - transmission

U2 - 10.1038/jes.2014.85

DO - 10.1038/jes.2014.85

M3 - Article

VL - 26

SP - 263

EP - 269

JO - Journal of Exposure Science and Environmental Epidemiology

JF - Journal of Exposure Science and Environmental Epidemiology

SN - 1559-0631

IS - 3

ER -

Bos MEH, Verstappen KM, Van Cleef BAGL, Dohmen W, Dorado-García A, Graveland H et al. Transmission through air as a possible route of exposure for MRSA. Journal of Exposure Science and Environmental Epidemiology. 2016;26(3):263-269. https://doi.org/10.1038/jes.2014.85