Transmission of new bovine prion to mice

T.G.M. Baron; A.G. Biacabe; A. Bencsik; J.P.M. Langeveld

doi:10.3201/eid1207.060107

Transmission of new bovine prion to mice

T.G.M. Baron, A.G. Biacabe, A. Bencsik, J.P.M. Langeveld

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrPres). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrPres molecular features distinct from BSE.

Original language	English
Pages (from-to)	1125-1128
Journal	Emerging Infectious Diseases
Volume	12
Issue number	7
DOIs	https://doi.org/10.3201/eid1207.060107
Publication status	Published - 2006

Keywords

creutzfeldt-jakob-disease
spongiform encephalopathy
molecular analysis
scrapie
protein
agent
bse

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3201/eid1207.060107

https://edepot.wur.nl/32466

TSE's (WOT-01-002-031, WOT-01-002-001.01)
van Keulen, L. (Project Leader)
1/01/08 → 31/12/25
Project: LVVN project

Cite this

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abstract = "We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrPres). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrPres molecular features distinct from BSE.",

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AU - Biacabe, A.G.

AU - Bencsik, A.

AU - Langeveld, J.P.M.

N1 - 000238639400013

PY - 2006

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AB - We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrPres). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrPres molecular features distinct from BSE.

KW - creutzfeldt-jakob-disease

KW - spongiform encephalopathy

KW - molecular analysis

KW - scrapie

KW - protein

KW - agent

KW - bse

U2 - 10.3201/eid1207.060107

DO - 10.3201/eid1207.060107

M3 - Article

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EP - 1128

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ER -

Transmission of new bovine prion to mice

Abstract

Keywords

UN SDGs

Access to Document

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Projects

TSE's (WOT-01-002-031, WOT-01-002-001.01)

Cite this