Transmission of new bovine prion to mice

T.G.M. Baron, A.G. Biacabe, A. Bencsik, J.P.M. Langeveld

    Research output: Contribution to journalArticleAcademicpeer-review

    48 Citations (Scopus)

    Abstract

    We previously reported that cattle were affected by a prion disorder that differed from bovine spongiform encephalopathy (BSE) by showing distinct molecular features of disease-associated protease-resistant prion protein (PrPres). We show that intracerebral injection of such isolates into C57BL/6 mice produces a disease with preservation of PrPres molecular features distinct from BSE.
    Original languageEnglish
    Pages (from-to)1125-1128
    JournalEmerging Infectious Diseases
    Volume12
    Issue number7
    Publication statusPublished - 2006

    Keywords

    • creutzfeldt-jakob-disease
    • spongiform encephalopathy
    • molecular analysis
    • scrapie
    • protein
    • agent
    • bse

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