Transmission of highly pathogenic avian influenza H5N1 virus in Pekin ducks is significantly reduced by a genetically distant H5N2 vaccine

J.A. van der Goot, M. van Boven, A. Stegeman, S.G.P. van de Water, M.C.M. de Jong, G. Koch

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)

Abstract

Domestic ducks play an important role in the epidemiology of H5N1 avian influenza. Although it is known that vaccines that have a high homology with the challenge virus are able to prevent infection in ducks, little is yet known about the ability of genetically more distant vaccines in preventing infection, disease, and transmission. Here we study the effect of a widely used H5N2 vaccine (A/Chicken/Mexico/232/94/CPA) on the transmission of H5N1 virus (A/Chicken/China/1204/04) in ducks. The quantitative analyses show that despite the low level of homology between the virus and vaccine strain transmission was significantly reduced two weeks after a single or double vaccination. Mortality and disease rates were reduced markedly already one week after a single vaccination.
Original languageEnglish
Pages (from-to)91-97
JournalVirology
Volume382
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • domestic ducks
  • inactivated vaccines
  • reverse genetics
  • a viruses
  • chickens
  • evolution
  • efficacy
  • turkeys
  • asia
  • quantification

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