Transmission of F4+ E. coli in groups of early weaned piglets

P.L. Geenen; D. Döpfer; J. van der Meulen; M.C.M. de Jong

doi:10.1017/S0950268804003292

Transmission of F4+ E. coli in groups of early weaned piglets

P.L. Geenen, D. Döpfer, J. van der Meulen, M.C.M. de Jong

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

The aim of this study was to estimate transmission parameters of enterotoxigenic F4+ Escherichia coli F4 (F4+ E. coli) in groups of early weaned piglets with F4-receptor-positive (F4R+) and F4-receptor-negative piglets (F4R[minus sign]). Transmission of F4+ E. coli was quantified in four heterogeneous groups of F4R+ and F4R[minus sign] piglets. Infectiousness was determined by the number of F4+ E. coli/g faeces shed during 8 days. Transmission parameters were estimated using generalized linear models assuming a stochastic SIR model. F4R+ piglets were found to be more susceptible than F4R[minus sign] piglets, but F4R+ and F4R[minus sign] piglets were not different in infectiousness. The reproduction ratios for homogeneous F4R+ and F4R[minus sign] populations were estimated as 6·37 (95% CI 1·89¿21·48) and 0·02 (95% CI 0·00¿1·13) respectively. The implication of these results is that in order to prevent major outbreaks, the fraction of F4R+ piglets should be small (approximately 10% or less). Therefore, selective breeding programmes could contribute to reducing F4+ E. coli-related diarrhoea and transmission.

Original language	English
Pages (from-to)	459-468
Number of pages	10
Journal	Epidemiology and Infection
Volume	133
Issue number	3
DOIs	https://doi.org/10.1017/S0950268804003292
Publication status	Published - 2005

Keywords

postweaning diarrhea
intestinal receptor
brush-borders
pigs
adhesion
k88
prevalence
phenotypes
diseases
fimbriae

Access to Document

10.1017/S0950268804003292

Fingerprint Dive into the research topics of 'Transmission of F4+ E. coli in groups of early weaned piglets'. Together they form a unique fingerprint.

Cite this

@article{492cd294f1b64ed2a125e2a10c8c9b78,

title = "Transmission of F4+ E. coli in groups of early weaned piglets",

abstract = "The aim of this study was to estimate transmission parameters of enterotoxigenic F4+ Escherichia coli F4 (F4+ E. coli) in groups of early weaned piglets with F4-receptor-positive (F4R+) and F4-receptor-negative piglets (F4R[minus sign]). Transmission of F4+ E. coli was quantified in four heterogeneous groups of F4R+ and F4R[minus sign] piglets. Infectiousness was determined by the number of F4+ E. coli/g faeces shed during 8 days. Transmission parameters were estimated using generalized linear models assuming a stochastic SIR model. F4R+ piglets were found to be more susceptible than F4R[minus sign] piglets, but F4R+ and F4R[minus sign] piglets were not different in infectiousness. The reproduction ratios for homogeneous F4R+ and F4R[minus sign] populations were estimated as 6·37 (95% CI 1·89¿21·48) and 0·02 (95% CI 0·00¿1·13) respectively. The implication of these results is that in order to prevent major outbreaks, the fraction of F4R+ piglets should be small (approximately 10% or less). Therefore, selective breeding programmes could contribute to reducing F4+ E. coli-related diarrhoea and transmission.",

keywords = "postweaning diarrhea, intestinal receptor, brush-borders, pigs, adhesion, k88, prevalence, phenotypes, diseases, fimbriae",

author = "P.L. Geenen and D. D{\"o}pfer and {van der Meulen}, J. and {de Jong}, M.C.M.",

year = "2005",

doi = "10.1017/S0950268804003292",

language = "English",

volume = "133",

pages = "459--468",

journal = "Epidemiology and Infection",

issn = "0950-2688",

publisher = "Cambridge University Press",

number = "3",

}

TY - JOUR

T1 - Transmission of F4+ E. coli in groups of early weaned piglets

AU - Geenen, P.L.

AU - Döpfer, D.

AU - van der Meulen, J.

AU - de Jong, M.C.M.

PY - 2005

Y1 - 2005

N2 - The aim of this study was to estimate transmission parameters of enterotoxigenic F4+ Escherichia coli F4 (F4+ E. coli) in groups of early weaned piglets with F4-receptor-positive (F4R+) and F4-receptor-negative piglets (F4R[minus sign]). Transmission of F4+ E. coli was quantified in four heterogeneous groups of F4R+ and F4R[minus sign] piglets. Infectiousness was determined by the number of F4+ E. coli/g faeces shed during 8 days. Transmission parameters were estimated using generalized linear models assuming a stochastic SIR model. F4R+ piglets were found to be more susceptible than F4R[minus sign] piglets, but F4R+ and F4R[minus sign] piglets were not different in infectiousness. The reproduction ratios for homogeneous F4R+ and F4R[minus sign] populations were estimated as 6·37 (95% CI 1·89¿21·48) and 0·02 (95% CI 0·00¿1·13) respectively. The implication of these results is that in order to prevent major outbreaks, the fraction of F4R+ piglets should be small (approximately 10% or less). Therefore, selective breeding programmes could contribute to reducing F4+ E. coli-related diarrhoea and transmission.

AB - The aim of this study was to estimate transmission parameters of enterotoxigenic F4+ Escherichia coli F4 (F4+ E. coli) in groups of early weaned piglets with F4-receptor-positive (F4R+) and F4-receptor-negative piglets (F4R[minus sign]). Transmission of F4+ E. coli was quantified in four heterogeneous groups of F4R+ and F4R[minus sign] piglets. Infectiousness was determined by the number of F4+ E. coli/g faeces shed during 8 days. Transmission parameters were estimated using generalized linear models assuming a stochastic SIR model. F4R+ piglets were found to be more susceptible than F4R[minus sign] piglets, but F4R+ and F4R[minus sign] piglets were not different in infectiousness. The reproduction ratios for homogeneous F4R+ and F4R[minus sign] populations were estimated as 6·37 (95% CI 1·89¿21·48) and 0·02 (95% CI 0·00¿1·13) respectively. The implication of these results is that in order to prevent major outbreaks, the fraction of F4R+ piglets should be small (approximately 10% or less). Therefore, selective breeding programmes could contribute to reducing F4+ E. coli-related diarrhoea and transmission.

KW - postweaning diarrhea

KW - intestinal receptor

KW - brush-borders

KW - pigs

KW - adhesion

KW - k88

KW - prevalence

KW - phenotypes

KW - diseases

KW - fimbriae

U2 - 10.1017/S0950268804003292

DO - 10.1017/S0950268804003292

M3 - Article

VL - 133

SP - 459

EP - 468

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 3

ER -