Translating the human microbiome

J. Brown, W.M. de Vos, P.S. Distefano, J. Doré, C. Huttenhower, R. Knight, T.D. Lawley, J. Raes, P. Turnbaugh

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19 Citations (Scopus)

Abstract

Over the past decade, an explosion of descriptive analyses from initiatives, such as the Human Microbiome Project (HMP) and the MetaHIT project, have begun to delineate the human microbiome. Inhabitants of the intestinal tract, nasal passages, oral cavities, skin, gastrointestinal tract and urogenital tract have been identified using whole genome sequencing, cultivation, metagenomics, metatranscriptomics, metaproteomics and metabolomics. Generation of these data has led to an improved understanding of the contribution of the human microbiome to physiology, health and disease. Nature Biotechnology approached several experts to seek their views on what steps need to be taken to move from descriptive microbiome biology to targeted therapies that tackle diseases in which microbiome dysfunction is a contributory factor
Original languageEnglish
Pages (from-to)304-308
JournalNature Biotechnology
Volume31
Issue number4
DOIs
Publication statusPublished - 2013

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Brown, J., de Vos, W. M., Distefano, P. S., Doré, J., Huttenhower, C., Knight, R., ... Turnbaugh, P. (2013). Translating the human microbiome. Nature Biotechnology, 31(4), 304-308. https://doi.org/10.1038/nbt.2543