The intake of nicotine by smoking cigarettes is modelled by a dynamical system of differential equations. The variables are the internal level of nicotine and the level of craving. The model is based on the dynamics of neural receptors and the way they enhance craving. Lighting of a cigarette is parametrised by a time-dependent Poisson process. The nicotine intake rate is assumed to be proportional with the parameter of this stochastic process. The effect of craving is damped by a control mechanism in which awareness of the risks of smoking and societal measures play a role. Fluctuations in this damping may cause transitions from smoking to non-smoking and vice versa. With the use of Monte Carlo simulation the effect of abrupt and gradual cessation therapies are evaluated. Combination of the two in a mixed scheme yields a therapy with a duration that can be set at wish.
- nicotinic acetylcholine-receptors
- quit smoking
- tobacco use
Grasman, J., Grasman, R. P. P. P., & van der Maas, H. L. J. (2012). Transitions in smoking behaviour and the design of cessation schemes. PLoS ONE, 7(10), [e47139]. https://doi.org/10.1371/journal.pone.0047139