Transcriptomic microarray analysis of BoMac cells after infection with bovine foamy virus

M. Rola-Luszczak, M. Materniak, A. Pluta, M.M. Hulst, J. Kuz'mak

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2 Citations (Scopus)

Abstract

Bovine foamy virus (BFV) infections are highly prevalent among cattle worldwide. However, relatively little is known about the impact of this virus on the host immune system. In our study, we focused on a bovine macrophage cell line (BoMac) and examined changes in the BoMac transcriptome after in vitro infection with BFV using bovine BLOPlus oligo microarrays. One hundred twenty-four genes showed significant changes in expression level. The biological process categories found to be enriched include metabolic processes, cell communication, transport, immune system processes, and response to extracellular stimuli. RT-qPCR was applied to confirm the results obtained for representative genes.
Original languageDutch
Pages (from-to)1515-1519
JournalArchives of Virology
Volume159
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • leukemia-virus
  • peripheral-blood
  • gene-expression
  • syncytial virus
  • up-regulation
  • cattle
  • identification
  • apobec3
  • lymphocytes
  • taxilin

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