Cardiovascular research using the zebrafish (Danio rerio) as model species has made important contributions to cardiac cell specification, regeneration and function over the last decade. However, the response of the adult zebrafish heart to exercise, known in mammals to elicit important adaptations in this tissue, has not been evaluated to date. Our group is investigating the physiological effects of swimming in adult zebrafish and recently established a swim-training protocol under sustained exercise conditions (i.e. optimal swimming speed) (Palstra et al. PloS One, 5:e14483, 2010). Under these conditions, we subjected adult zebrafish to 20 days of swim-training and analyzed the transcriptomic response in the zebrafish heart by microarray analysis. We identified more than seven hundred differentially expressed genes involved in processes such as cell cycle and proliferation, extracellular matrix and cytoskeleton, muscle contraction, growth factors/signalling pathways and metabolism. These results provide insights into the molecular adaptative mechanisms taking place in the zebrafish heart in response to swimming-induced activity.
|Title of host publication||Book of abstracts of the International Congress on the Biology of Fish, 03-07 August 2014, Edinburgh, United Kingdom|
|Publication status||Published - 2014|
|Event||11th International Congress on the Biology of Fish, Edinburgh, United Kingdom - |
Duration: 3 Aug 2014 → 7 Aug 2014
|Conference||11th International Congress on the Biology of Fish, Edinburgh, United Kingdom|
|Period||3/08/14 → 7/08/14|