Transcription factor dosage: more or less sufficient for growth

Hugo F. Hofhuis, Renze Heidstra

Research output: Contribution to journalReview articleAcademicpeer-review

1 Citation (Scopus)

Abstract

Recent findings highlight three instances in which major aspects of plant development are controlled by dosage-dependent protein levels. In the shoot apical meristem the mobile transcription factor WUS displays an intricate function with respect to target regulation that involves WUS dosage, binding site affinity and protein dimerization. The size of the root meristem is controlled by dosage-dependent PLT protein activity. Recent identification of targets and feedbacks provide new insights and entry into possible mechanisms of dosage read-out. Finally, HD-ZIPIII dosage, enforced by a gradient of mobile miRNAs, presents a relatively unexplored case in the radial patterning of vasculature and ground tissue. We evaluate our current knowledge of these three examples and address molecular mechanisms of dosage translation where possible.

Original languageEnglish
Pages (from-to)50-58
JournalCurrent Opinion in Plant Biology
Volume45
DOIs
Publication statusPublished - Oct 2018

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transcription factors
dosage
dimerization
root meristems
proteins
shoot meristems
apical meristems
translation (genetics)
plant development
binding sites

Cite this

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Transcription factor dosage : more or less sufficient for growth. / Hofhuis, Hugo F.; Heidstra, Renze.

In: Current Opinion in Plant Biology, Vol. 45, 10.2018, p. 50-58.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Transcription factor dosage

T2 - more or less sufficient for growth

AU - Hofhuis, Hugo F.

AU - Heidstra, Renze

PY - 2018/10

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AB - Recent findings highlight three instances in which major aspects of plant development are controlled by dosage-dependent protein levels. In the shoot apical meristem the mobile transcription factor WUS displays an intricate function with respect to target regulation that involves WUS dosage, binding site affinity and protein dimerization. The size of the root meristem is controlled by dosage-dependent PLT protein activity. Recent identification of targets and feedbacks provide new insights and entry into possible mechanisms of dosage read-out. Finally, HD-ZIPIII dosage, enforced by a gradient of mobile miRNAs, presents a relatively unexplored case in the radial patterning of vasculature and ground tissue. We evaluate our current knowledge of these three examples and address molecular mechanisms of dosage translation where possible.

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DO - 10.1016/j.pbi.2018.05.008

M3 - Review article

VL - 45

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JO - Current Opinion in Plant Biology

JF - Current Opinion in Plant Biology

SN - 1369-5266

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