Trans meets cis in MADS science

S. de Folter, G.C. Angenent

    Research output: Contribution to journalArticleAcademicpeer-review

    143 Citations (Scopus)


    The interaction between a transcription factor and its binding site at the DNA is an integral part of transcriptional regulatory networks, which is fundamental for an understanding of biological processes. An example is the family of MADS domain transcription factors, which represent key regulators of processes in yeast, animals and plants. However, despite our extensive knowledge of these transcription factors, limited information is available on the cis-elements to which these proteins bind or how these elements are defined. Here, we discuss the current understanding of MADS protein binding sites and compare data from various organisms. This information can help us in developing algorithms to predict binding sites for MADS domain transcription factors, which would be a significant step forward in the identification of `down-stream¿ target genes and the elucidation of transcriptional networks
    Original languageEnglish
    Pages (from-to)224-231
    JournalTrends in Plant Science
    Issue number5
    Publication statusPublished - 2006


    • floral organ identity
    • transcriptional regulatory networks
    • ternary complex-formation
    • homeotic gene apetala3
    • dna-binding specificities
    • cell-fate determination
    • box genes
    • flower development
    • in-vitro
    • chromatin immunoprecipitation


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